ChemInform Abstract: STUDIES ON QUINOLINE DERIVATIVES AND RELATED COMPOUNDS. 5. SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NOVEL 1‐ALKOXY‐1,4‐DIHYDRO‐4‐OXO‐3‐QUINOLINECARBOXYLIC ACIDS

Agui, Hideo; Mitani, T.; Izawa, A; Komatsu, Teiko; Nakagome, Takenari

doi:10.1002/chin.197742211

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2023

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“…Frequent literature survey evidenced the various pharmacology of diverse nitrogen, sulphur, bearing heteroatomic mimics. Furthermore, substituted heterocyclic moieties bearing thiadiazole [1][2][3][4][5][6][7][8][9] , quinoline [10][11][12][13][14][15][16][17] and piperazine [18][19][20][21][22][23][24] demonstrated great biological profiles. uses viz.…”

Section: Introductionmentioning

confidence: 99%

1,3,4-Thiadiazole: A Promising Pharmacophore

Chaudhary

Dubey²,

Ram³

et al. 2023

Orient. J. Chem

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Active pharmaceutical ingredients (A.P.I.) are made up of various heteroatomic moieties. Numerous heterocycle scaffolds are regarded as crucial structures. More frequently, presence of various heteroatoms viz. nitrogen, sulphur, halogens, and oxygen atoms at different position in 5- or 6-membered rings contributed them as valued source of therapeutic profiles in literature of medicinal chemistry. In the current study, numerous novels 1,3,4-thiadiazole derivatives were created using a multi-step synthetic method. These thiadiazole derivatives comprised 2-amino-5-phenyl-1,3,4-thiadiazole, piperazine, acetophenones, and quinolin-5-ol. 1H-NMR, IR, Mass, and elemental analyses were used to describe these thiadiazole derivatives (C, H, N). The antibacterial, antifungal, and insecticidal efficacy of thiadiazole 4a-4i mimics was investigated.

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