ChemInform Abstract: Study on the Tandem Synthesis of Optically Active 2‐Substituted 4 (or 5)‐Phenyl‐1,3‐oxazolines.

Abstract

Study on the Tandem Synthesis of Optically Active 2-Substituted 4 (or 5)-Phenyl--1,3-oxazolines. -The proposed mechanism for this reaction involves an aziridine intermediate with the acidities of the carboxylic acids playing a key role in the selective formation of various intermediates. While the halogenated acetic acid derivatives (V) can be employed in this reaction, acetic acid itself does not yield the desired product. -(JIANG*, H.; LU, W.; CAI, Y.; WAN, W.; WU, S.; ZHU, S.; HAO, J.; Tetrahedron 69 (2013) 9, 2150-2156, http://dx.