ChemInform Abstract: Synthesis, Aggregation Properties, and Antiprotozoal Activity of Heterocyclic Heterogemini Surfactants (I).

Lukáč, Miloš; Timko, Lukáš; Mrva, Martin; Ondriska, František; Karlovská, Janka; Valentová, Jindra; Lacko, I.

doi:10.1002/chin.201033187

Cited by 2 publications

(2 citation statements)

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“…Although there exists a few reports on the physicochemical properties of these surfactants [30,[34][35][36][37], this is probably the first detailed study of mixed systems of these surfactants with a drug.…”

Section: Introductionmentioning

confidence: 99%

Interaction between Zwitterionic Surfactants and Amphiphilic Drug: A Tensiometric Study

Ansari

Noori

Naqvi³

et al. 2013

Zeitschrift Für Physikalische Chemie

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Amitriptyline Hydrochloride / Zwitterionic Gemini Surfactants / Surface Tension / Mixed MicellesThe physicochemical properties, viz, critical micelle concentration (cmc), surface excess concentration (Γ max ), minimum area per head group ( A min ) of zwitterionic surfactants (designated as n(−)-2-m(+); n = 8, 10, 12 and m = 12, 14, 16) and their mixtures with amphiphilic antidepressant drug amitriptyline hydrochloride (AMT) were determined by using surface tension measurements. The cmc and ideal cmc (cmc id ) values along with interaction parameters, β m and β σ (calculated using Rubingh's and Rosen's models), suggest attractive interactions among the components. The Krafft temperature measurements also indicate strong attractive interactions. Γ max (or A min ) increases (or decreases) with the addition of gemini surfactant; the values being closer to that of the drug. These values and micellar mole fraction (X m 1 -calculated from Rubingh's model and X Moto 1 -calculated from Motomura's model) indicate larger contribution of gemini surfactants in mixed micelles and smaller contribution at air/solution interface (as mole fraction values at interface, X σ 1 , are slightly smaller than X m 1 ). The standard Gibbs energy of micellization (ΔG • mic ) and adsorption (ΔG • ad ) as well as excess energy of mixing (ΔG m ex ) are all negative. All these results suggest higher stability of the mixed systems. UV absorbance results also suggest that the mixed micelles are stable for several days.

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Section: Introductionmentioning

confidence: 99%

Interaction between Zwitterionic Surfactants and Amphiphilic Drug: A Tensiometric Study

Ansari

Noori

Naqvi³

et al. 2013

Zeitschrift Für Physikalische Chemie

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“…Amphiphiles have very good surfactant property and wide industrial applications (Figure 1) such as in detergents, 5,6 cosmetics, 7 skin-care products, 8 shampoo preparations, [9][10][11] etc. They also show wide variety of biological activities, such as antifungal, [12][13][14] antibacterial, 14,[15][16][17][18] antiparasitic, 19,20 cytotoxic, 14,21 etc.…”

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confidence: 99%

One-Pot Synthesis of Cationic Amphiphiles from n-Alcohols and Allyl Alcohols

Narender¹,

Tripathi²,

Madhur³

et al. 2011

Synlett

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A novel, efficient one-pot method has been developed to synthesize amphiphiles such as N-alkylated/N-allylated triethylamines and pyridinium salts for the first time from n-alcohols and naturally occurring terpenes (allyl alcohols) in good yields. These amphiphiles have got industrial application as surfactants, DNA carriers, and other biological applications. The DNA delivery efficacy and cytotoxicity of N-alkylated and N-allylated triethylamine and pyridinium salts were studied.

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ChemInform Abstract: Synthesis, Aggregation Properties, and Antiprotozoal Activity of Heterocyclic Heterogemini Surfactants (I).

Abstract: Synthesis, Aggregation Properties, and Antiprotozoal Activity of Heterocyclic Heterogemini Surfactants (I). -(LUKAC*, M.; TIMKO, L.; MRVA, M.; ONDRISKA, F.; KARLOVSKA, J.; VALENTOVA, J.; LACKO, I.; Heteroat. Chem.

Cited by 2 publications

References 1 publication

Interaction between Zwitterionic Surfactants and Amphiphilic Drug: A Tensiometric Study

Interaction between Zwitterionic Surfactants and Amphiphilic Drug: A Tensiometric Study

One-Pot Synthesis of Cationic Amphiphiles from n-Alcohols and Allyl Alcohols

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