ChemInform Abstract: Synthesis and Amination of 1‐Alkyl‐6‐nitro‐4‐oxo‐7‐chloro‐1,4‐ dihydroquinoline‐3‐carboxylic Acids.

Abstract

Synthesis and Amination of 1-Alkyl-6-nitro-4-oxo-7-chloro-1,4dihydroquinoline-3-carboxylic Acids.-A facile and efficient synthesis of the title 7-chloroquinolinecarboxylic acids (VI) and some examples of the direct substitution of the 7-chlorine atom by N-(→ (VIII), (IX)) and O-nucleophiles (→ (XI)) are given. Some of the obtained quinoline derivatives display significant antibacterial activity. -(GLUSHKOV, R. G.; MARCHENKO, N. B.; LEVSHIN, I. B.; DRONOVA, L. N.; Khim.-Farm. Zh. 31 (1997) 5, 48-52; Tsentr. khim. lek. sredstv. Vseross. nauchno-issled. khim.-farm. inst., Moskva, Russia; RU)