ChemInform Abstract: Synthesis and Antimicrobial Activity of Quinoxaline Based Thiazolidinones and Azetidinones.

Abstract

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Solvent Free Microwave Accelerated Synthesis of Heterocyclic Thiazolidin-4-ones as Antimicrobial and Antifungal Agents

“…All synthesized compounds were screened for antibacterial activity by cup-plate agar diffusion method 28 against gram-positive species Staphylococcus aureu, and Bacillus subtilis and gram-negative species Escherichia coli, Pseudomonas aerogenosa and Klebsilla aerogenes in the concentration of 25 µg/ mL. These compounds were also screened for antifungal activity against fungi Aspergillus niger, Aspergillus flavus and Candida albican by the paper disc diffusion method 29 in the same concentration. The activities were compared with standard drugs Ciprofloxacin, Norfloxacin, Salicylic acid and Clotrimazole.…”

Synthesis and In Vitro Antimicrobial Screening of New Azetidin‐2‐ones of 5‐Ethyl Pyridine‐2‐ethanol

“…The β ‐lactum (2‐azetidinone) skeleton is the key structural unit in penicillins (e.g., amoxicillin (AMOX), ampicillin (AMP), penicillin G (PEN G), oxacillin (OXA), and cloxacillin (CLOX)), and cephalosporins (e.g., cephapirin (CEP)) for antimicrobial agents. In penicillins and cephalosporins, β ‐lactam ring is responsible for the antibacterial activity; besides this, 2‐azetidinone‐containing compounds were reported for antimicrobial , anti‐inflammatory , analgesic, CNS depressant, and muscle relaxant activities . Pyridine derivatives also exhibit various biological activities such as anticancer , anticonvulsant , antiproliferative , and also used as γ‐secretase modulators , JAK2 kinase inhibitors , cyclooxygenase‐2 (COX‐2) inhibitors , and so forth.…”

Synthesis of 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)acetamide-based azetidinone derivatives as potent antibacterial and antifungal agents

“…Quinoxaline ring is a part of various antibiotics such as hinomycin, levomycin, and actinoleutin that are known to inhibit growth of Gram positive bacteria and are active against various transplantable tumours. [1][2][3][4][5][6][7] Quinoxaline derivatives have also been found to be associated with a wide variety of biological activities including antifungal, [8][9][10] antibacterial, [10][11][12][13][14] antitubercular, 8,9,[15][16][17][18] antiinflammatory agents. 19 Further, hydrazinoquinoxalines and their cyclic analogues have been reported as antimicrobial agents.…”