ChemInform Abstract: Synthesis and Antiproliferative Activity of Novel α‐Aminophosphonates.

Abstract

A novel series of carbazole‐based α‐aminophosphonates (IV) (14 examples) are synthesized via a three‐component coupling reaction in PEG 400 as green reaction medium.

Synthesis of Biologically Active α-Aminophosphonates

“…A novel series of carbazole containing aminophosphonate derivatives (28) was synthesized [38] by three component coupling of 6-bromo-9-ethyl-9H-carbazole-3-carbaldehyde (27), various aromatic amines and diethyl phosphite using polyethylene glycol (PEG-400) as a green reaction (Scheme 15). The advantages of this method are simple and mild experimental conditions, avoiding hazardous solvents and toxic organic reagents.…”

“…The advantages of this method are simple and mild experimental conditions, avoiding hazardous solvents and toxic organic reagents. The antiproliferative activity of these molecules was evaluated against the cancer cell lines A549, MCF-7 and NCI-N87 [38].…”