ChemInform Abstract: Synthesis and Antitumor Activity of Benzimidazolyl‐1,3,5‐triazine and Benzimidazolylpyrimidine Derivatives.

Abstract

Synthesis and Antitumor Activity of Benzimidazolyl-1,3,5-triazine and Benzimidazolylpyrimidine Derivatives.-A range of 2benzimidazolyl-1,3,5-triazine (V) (7 examples) and -pyrimidine derivatives (X) (3 examples) are synthesized by appropriate nucleophilic substitution reactions and evaluated for their cytotoxicity against some human cancer and murine leukemia cell lines and aromatase inhibitory activity. -(MATSUNO,

Structures and properties of benzimidazole derivatives from invariom modelling

“…the anti-ulcer drug omeprazole gave rise to lasting interest in this class of compounds. [1][2][3][4][5] Our continuing research on synthesis and reactions of benzimidazole derivatives led to investigations in arylsulfonation of 5 -(chloro, nitro, methyl)-2-alkylbenzimidazoles. To further investigate the nature of chemical bonds and of intermolecular interactions in these derivatives [6] we had carried out single-crystal X-ray structure d e t e r m i n a t i o n s in the past.…”