ChemInform Abstract: Synthesis and Antitumor Activity of Fused Tetracyclic Quinoline Derivatives. Part 1.

Abstract

ChemInform Abstract Chlorination of the tricyclic ketones (I) followed by coupling with the amine (II) gives the fused quinoline derivatives (III) with an amino side chain. The sulfur analogue (VIII) is prepared from anthranilic acid (IV) as outlined in the reaction scheme. Some of the fused tetracyclic quinoline derivatives (IX), which are prepared by similar procedures, show potent antitumor activities in vitro and in vivo.