ChemInform Abstract: Synthesis and Antitumor Activity of 6‐p‐Alkoxyphenyl Derivatives of Hexahydropyrimidine‐2,4‐diones.

Abstract

Synthesis and Antitumor Activity of 6-p-Alkoxyphenyl Derivatives of Hexahydropyrimidine-2,4-diones. -The title pyrimidinediones (III) and (VI), synthesized by intermolecular cyclization of the β-amino acids (I) and (V), resp., with urea are tested for their activity against various tumor cell lines. A detailed structure-activity-relationship study is presented to explain the results. -(AZARYAN, L. V.; AVETISYAN, S. A.; BUYUKYAN, N. S.; CHACHOYAN, A. A.; GARIBDZHANYAN, B. T.; Khim.-Farm. Zh. 31 (1997) 6, 8-10; Inst. tonkoi org. khim. im. Mndzhoyana, Nats. Akad. nauk, Erevan 375014, Armenia; RU)