ChemInform Abstract: Synthesis and Biological Evaluation of 4‐Arylphthalazones Bearing Benzenesulfonamide and Anti‐Inflammatory and Anticancer Agents.

Abstract

The synthesized compounds are tested for their anti-inflammatory and anticancer activities. The compounds (IIIb) and (IIIf) show significant anti-inflammatory activity compared to the standard drug celecoxib. Further due to its high selectivity ratio compound (IIIb) can be used as template for the design of novel COX-2 enzyme inhibitors. The products (IIIc) and (IIIf) are screened for their antiproliferative activity toward 60 human cancer cell lines and they show mild activity against the renal cancer line UO-31. -(YASEEN, S.; OVAIS, S.; BASHIR, R.; RATHORE, P.; SAMIM, M.; SINGH, S.; NAIR, V.; JAVED*, K.; Arch. Pharm. (Weinheim, Ger.) 346 (2013) 6, 491-498, http://dx.doi.org/10.1002/ardp.201300056 ; Dep. Chem., Fac. Sci., Jamia Hamdard Univ., New Delhi 110 062, India; Eng.) -B. Voigt 42-066