ChemInform Abstract: Synthesis and Biological Evaluation of Some Novel N‐Aryl‐1,4‐dihydropyridines as Potential Antitubercular Agents.

Abstract

N-Aryldihydropyrimidines (IV), bearing an acetyl or a carbethoxy group at the 3-and 5-position of the dihydropyridine ring and a pyrazole ring at position 4, are synthesized to overcome the resistant isolates. Comparison of the in vitro antitubercular activities of the preliminarily screened compounds indicates that (IVg) is more potent than the first line antitubercular drug isoniazid. Compound (IVg) shows relatively low cytotoxicity. -(TRIVEDI*, A. R.; DODIYA, D. K.; DHOLARIYA, B. H.; KATARIA, V. B.; BHUVA, V. R.; SHAH, V. H.; Bioorg. Med. Chem. Lett. 21 (2011) 18, 5181-5183, http://dx.