ChemInform Abstract: Synthesis and Biological Applications of Hydroxamates

Abstract

Review: 146 refs.

Synthesis, characterization, and biological properties of oxidovanadium(IV) complexes of acetylsalicylhydroxamic acid (N-acetyloxy-2-hydroxybenzamide) as potential antimicrobials

“…The distinctive chelating ability 34,35 —due to keto–enol tautomerism exhibited by the hydroxamic and hydroximic forms 36 —and the vast spectrum of pharmacological, toxicological, and pathological properties of hydroxamic acids have fascinated researchers in the design of new complexes of biological relevance. 37–39…”

Contribution of Knoevenagel Condensation Products toward the Development of Anticancer Agents: An Updated Review

“…In the past few decades, various developments were achieved utilising different catalytic conditions, such as Lewis acid‐catalysed, nanocatalysts, organocatalysts and ionic liquids [27–29] . The Knoevenagel condensed products reached a stage of excellence in the field of medicinal chemistry, owing to their pharmacological properties such as antiviral, anti‐tubercular, anti‐Parkinson's, antidiabetic, antioxidant and anticancer activities [30–41] . Natural products like ajmalicine ( 1 , antihypertensive alkaloid) and pharmaceuticals like AMG 837 ( 2 , type II diabetes) and clinical agents such as atorvastatin ( 3 , cardiovascular disease), lumefantrine ( 4 , malaria) and sunitinib ( 5 , gastrointestinal stromal tumor) are the representatives prepared by utilising Knoevenagel reaction (Figure 1).…”

“…[27][28][29] The Knoevenagel condensed products reached a stage of excellence in the field of medicinal chemistry, owing to their pharmacological properties such as antiviral, anti-tubercular, anti-Parkinson's, antidiabetic, antioxidant and anticancer activities. [30][31][32][33][34][35][36][37][38][39][40][41] Natural products like ajmalicine (1, antihypertensive alkaloid) and pharmaceuticals like AMG 837 (2, type II diabetes) and clinical agents such as atorvastatin (3, cardiovascular disease), lumefantrine (4, malaria) and sunitinib (5, gastrointestinal stromal tumor) are the representatives prepared by utilising Knoevenagel reaction (Figure 1). [17,[42][43][44] Dr. Ramya Tokala was born in Vijayawada, Andhra Pradesh, India, in 1991.…”

Construction, petro-collecting/dispersing capacities, antimicrobial activity, and molecular docking study of new cationic surfactant-sulfonamide conjugates

“…1 ) with their SO 2 NH group bonded directly to aromatic ring are classified as one of the oldest agents with promising therapeutic effect [7] . Previously reported studies return their strong activities toward numerous biological systems such as malaria parasites [8] , tuberculosis [9] , cancer [10] , microbes [11] , and inflammation [12] to the presence of the sulfonamide group.…”