ChemInform Abstract: Synthesis and Biological Activity of Substituted 3‐Acylmethylene‐ and 3‐Hydroxy‐2‐indolones.

Abstract

Synthesis and Biological Activity of Substituted 3-Acylmethyleneand 3-Hydroxy-2-indolones.-The title compounds (III) and (V), resp., prepared by literature methods, are tested for their antimicrobial and antitumor activity. Only derivatives (IIIc), (Va), and (Vc) show antitumor activity while antimicrobial activity is observed for all derivatives depending on the substitution pattern. The best results are obtained for (IIIa) and (IIIb). -(KOZ'MINYKH, E. N.; BEREZINA, E. S.; KOLLA, V. E.; SHELENKOVA, S. A.; VORONINA, E. V.; KOZ'MINYKH, V. O.; Khim.-Farm. Zh. 31 (1997) 2, 31-36; Permskaya gos. farm. akad., Perm', Russia; RU)

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“…anti-viral, bacterio-static and anti-oxidative activity. 16,17 It is well established that many transition metals 18,19 and rare earth metals 20 amino acids complexes have considerable biological activity, such as antitumor properties. Although transition metal complexes of N-((benzoyl-amino)-thioxo-methyl)glycine 21,22 and rare earth metals 23 have been prepared.…”