ChemInform Abstract: Synthesis and Characterization of Some Biological Active Compounds on the Basis of 2‐Thiophene Carboxylic Acid with Heterocyclic Amines.

Abstract

Thioureides (IV) (8 examples) are obtained in a condensation reaction of 2‐thenoyl‐isocyanate with heterocyclic amines under optimized conditions.

Facile synthesis of quinazoline, oxazine and triazole derivatives as potential antimi-crobial agents based on isothiocyanate moiety

“…Heteroallenesisothiocyanatesareaninterestinggroupoforganiccompounds that are used asreactivekeyprecursors in the synthesis of heterocyclic molecules due to theirdiversereactionsandalsoto the ireasyavailability. [1][2][3][4] Isothiocyanatesare often prepared from thereactionofaminederivativeswithcarbondisulfide [5][6][7][8]orthiophosgene, [9][10][11] as well as treatmentofthecarboxylicacidderivativeswithammoniumthiocyantes [12][13][14][15][16][17].…”

Synthesis of novel hybrid pharmacophore of N ‐(( 4‐sulfamoylphenyl )carbamothioyl)alkanamides as potent carbonic anhydrase‐II and 15‐lipoxygenase inhibitors

“…Thioureas have ability to coordinate with different metal atoms as they are versatile monoanion, dianion, or neutral ligands (Arslan et al, 2009; Burrows et al, 1999; Henderson et al, 2002; Saeed & Hussain, 2013; Zuckerman & Bergman, 2000). These complexes have been screened for various biological actions such as analgesic, antihelmintic, antidepressant, antitussive, anticonvulsant, antihistaminic, and anesthetic (Badiceanu et al, 2010). Halogenated thioureas and coumarin‐linked thiourea derivatives have anticholinesterase potential (Iqbal et al, 2015; Saeed et al, 2015).…”

Synthesis of novel pyridazine derivatives as potential antimicrobial agents

“…[1] Also, phenethyl isothiocyanate and sulforaphane inhibit carcinogenesis and tumorigenesis in certain circumstances. [2] Several methods were employed in the synthesis of isothiocyanates, including the reaction of amine derivatives with carbon disulfide [3][4][5][6][7][8] or thiophosgene, [9][10][11] treatment of the carboxylic acid derivatives with ammonium thiocyantes [12][13][14][15] and pyrolysis of thiourea derivative in o-dichlorobenzene. [16] In addition, many natural isothiocyanates from plants were used as anticancer agents [17,18] and produced by enzymatic conversion of metabolites called glucosinolates.…”