ChemInform Abstract: Synthesis and Evaluation of Functionalized Aminobenzoboroxoles as Potential Anticancer Agents.

Suman, Pathi; Patel, Bhawankumar P.; Kasibotla, Agasthya V.; Solano, Lucas N.; Jonnalagadda, Subash C.

doi:10.1002/chin.201618178

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“…In this context, the development of the effective and stable new boron compounds for anticancer agents is one of the main targets for the scientist. Jonnalagadda and co‐workers prepared a series of novel functionalized aminobenzoboroxoles as potential anticancer agents . Jímenez‐Pérez et al .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of the Hemi‐Salen Ligands and Their Triboron Complexes: Spectroscopy and Examination of Anticancer Properties

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Durgun

et al. 2017

Chemistry & Biodiversity

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The synthesis, spectroscopic properties, and in vitro cytotoxicity activity of a series of various salen-based triboron complexes have been designed and prepared from hemi-salen (L 1 H 3 -L 4 H 3 ) ligands and BF 3 ÁEt 2 O or BPh 3 under simple reaction conditions. The hemi-salen (L 1 H 3 -L 4 H 3 ) ligands and their BF 2 or BPh 2 chelating triboron complexes were characterized by means of NMR ( 1 H, 13 C, 19 F, and 11 B) spectra, FT-IR spectra, UV/VIS spectra, fluorescence spectra, mass spectra, melting point, as well as elemental analysis. The triboron [L (1 -4) (BF 2 ) 3 ] and [L (1 -4) (BPh 2 ) 3 ] complexes were investigated for their absorption and emission properties, and these complexes are also good chelates towards boron(III) fragments such as BF 2 or BPh 2 quantum yield in solution reaching up to 38%. The hemisalen (L 1 H 3 -L 4 H 3 ) ligands and their BF 2 or BPh 2 chelating triboron complexes were tested for the in vitro anticancer activity against various cancer and normal cells (HeLa, DLD-1, ECC-1, PC-3, PNT-1A, and CRL-4010), and it was found that the cell viability of cancer cells was decreased while most of the healthy cells could still be viable. Also, the cytotoxicity studies showed that anticancer activity of hemi-salenligands showing the strongest cytotoxic effect in PC-3 cells were found to exhibit anticancer activity with apoptosis by increasing the level of ROS in the PC-3 cells.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of the Hemi‐Salen Ligands and Their Triboron Complexes: Spectroscopy and Examination of Anticancer Properties

Kılıç

Koyuncu

Durgun

et al. 2017

Chemistry & Biodiversity

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ChemInform Abstract: Synthesis and Evaluation of Functionalized Aminobenzoboroxoles as Potential Anticancer Agents.

Abstract: Starting from o‐boronobenzaldehyde, various N‐alkylated aminobenzoboroxole derivatives are synthesized by a reductive amination protocol.

Cited by 1 publication

References 1 publication

Synthesis and Characterization of the Hemi‐Salen Ligands and Their Triboron Complexes: Spectroscopy and Examination of Anticancer Properties

Synthesis and Characterization of the Hemi‐Salen Ligands and Their Triboron Complexes: Spectroscopy and Examination of Anticancer Properties

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