ChemInform Abstract: Synthesis and Local Anesthetic Activity of o‐(Cyclopentenyl) and o‐(Cyclopentyl)aniline Derivatives.

Abstract

Synthesis and Local Anesthetic Activity of o-(Cyclopentenyl) ando-(Cyclopentyl)aniline Derivatives.-The synthesis of cyclopentylor cyclopentenyl-substituted N-piperidinylacetanilides (VI), (VII), and tricyclic analogue (VIII) is achieved as described for derivatives (VI) by chloroacetylation of the corresponding anilines (II) followed by amide formation with piperidine. The novel compounds possess local anesthetic activity. -(GATAULLIN, R. R.; KAZHANOVA, T. V.; KARACHURINA, L. T.; IL'YASOVA, L. T.; DAVY-DOVA, V. A.; SAPOZHNIKOVA, T. A.; ZARUDII, F. S.; ABDRAKHMANOV, I. B.; Khim.-Farm. Zh. 35 (2001) 9, 28-32; Inst. org. khim. Ural. otd. Ross.