ChemInform Abstract: Synthesis and Microbial Activity of New Thiazolyl‐1,4‐benzothiazines.

Abstract

Synthesis and Microbial Activity of New Thiazolyl-1,4-benzothiazines. -Some new thiazolyl-1,4-benzothiazines (VI) are synthesized via oxidative cyclocondensation of diones (IV) with 2-aminobenzenethiol (V) and evaluated for their antibacterial and antifungal activity in vitro. -(DENGLE, R. V.; INGLE, R. D.; BONDGE, S. P.; MANE, R. A.; Indian J. Chem., Sect. B: Org.

Base induced synthesis of 4H-1,4-benzothiazines and their computational studies

“…The optimized molecular geometry, 1 H NMR and 13 C NMR calculations were performed using Gaussian 09W 16 by DFT methods with the B3LYP (Beck three parameter Lee-Yang-Parr) exchange correlation functional, which combines the hybrid exchange functional of Becke, 17 with the gradient-correlation functional of Lee et al 18 The 6-31G(d) basis set was used for calculations in the gas phase of the structure 3(c). The optimized geometry using the 6-31G(d) basis set was used in the 1 H and 13 C NMR calculations using DFT to characterize all stationary points as minima. The calculated geometrical parameters viz.…”

“…Ultrasonication enables optimization, avoids toxicity, reduces multistep reactions to a single step, and forms less byproducts. [2][3][4][5][6]9,[11][12][13][14][15] The present paper discusses the synthesis of 1,4-benzothiazine derivatives using a greener synthetic pathway, i.e. an ultrasonication method, and their characterization using NMR, IR, UV-vis and uorescence spectroscopy and mass spectrometry.…”

“…Also, single crystal X-ray diffraction and computational studies were done. 1 H and 13 C NMR are basic tools for the structural elucidation of any organic molecule. So, the experimental and calculated chemical shis obtained are correlated to conrm the structure of the compound 3(c).…”

Synthesis and biological activities of some 3,5-diaryl-N-hydroxy-tetrahydro-1,4-thiazine-1,1-dioxides

“…It is well known that molecules containing nitrogen, sulfur and other members of heteroatoms exhibit a variety of biological activities (Katritzky, 1965;Prot and Thomson, 1976;Faria et al, 1979). A large group of thiazines, benzothiazines and phenothiazines have antihistaminic, antihyper--tensive, diuretic, antipsychotic and antimicrobial effects (Matier et al, 1974;Kaverling Busiman, 1982;Klaus and Erik, 1982;Bertran Katzen, 1995;Dayle;Dengle et al, 1999).…”

Synthesis, Characterization, and Biological Activity of Substituted Thiazole-5-carboxaldehydes and Their Ylidenenitriles Derivatives

“…5-10 A detailed literature survey 11,12 reveals that a large number of thiazole derivatives containing other heterocyclic systems have been designed, synthesized, and evaluated for their antimicrobial activity involving several strains of bacteria, fungi, and viruses. [13][14][15][16][17] The Vilsmeier-Haack reaction in micellar media 18,19 plays an important role for synthesizing a variety of aromatic and biologically active Substituted Thiazole-5-carboxaldehydes 2721 heterocyclic compounds in good yield with improved reaction time. Micelles by their solubilization capacity increase the reactant concentration within the hydrophilic or hydrophobic micellar regions facilitating the reactions.…”