ChemInform Abstract: Synthesis and Pharmacological Evaluation of Some Dihydropyran Carboxylic Acids.

Abstract

201 ChemInform Abstract The synthesis of the (dihydro)pyrancarboxylic acids (I), (V), and (VII) from the methyl ester (II) is reported. All three acids show various pharmacological activities.

Efficient tandem synthesis of a variety of pyran-annulated heterocycles, 3,4-disubstituted isoxazol-5(4H)-ones, and α,β-unsaturated nitriles catalyzed by potassium hydrogen phthalate in water

“…When ethyl 4-chloroacetoacetate (17) was used instead of ethyl acetoacetate (14) the 3CR proceeded furnishing another type of 3,4-disubstituted isoxazol-5(4H)-one derivative (entries [15][16][17][18][19][20][21][22][23]. The results for this 3CR are presented in Table 7.…”

“…Over the past few years, both these six-membered oxygen-containing heterocycles and their derivatives have attracted much attention, owing to their wide range of biological activity, for example spasmolytic, diuretic, anticoagulant, antianaphylactic [13], antimicrobial [14], antifungal [15], antibacterial [16], antioxidant [17], antileishmanial [18], antitumor [19], local anesthetic [20], antihistaminic [21], and antiallergenic [22] activity and because of their use for treatment of Alzheimer's disease [23] and schizophrenia [24]. Moreover, several chromenes are widely used as pigments [25], cosmetics [26], and laser dyes [27].…”

One pot synthesis of substituted 1H-benzo[f]chromen-3-yl-2H-chromen-2-one derivatives

“…Chromene derivatives are known to exhibit a wide range of biological activities, such as antifungal, antibacterial [1][2][3][4][5], antioxidative [6], antileishmanial [7], antitumor [8,9], hypotensive [9], antiproliferation [10,11], local anesthetic [12], antiallergenic [13,14], central nervous system activities and effects [15], as well as efficacious in the treatment of Alzheimer's disease [16] and schizophrenia disorder [17]. Coumarins are of scientific interest as anti-HIV agents [18], antituberculosis agents [19], cholinesterase and monoamine oxidase inhibitors [20], antioxidants and anti-inflammatory [21,22].…”

Heteroaromatization with 4-phenyldiazenyl-1-naphthol. Part II: Synthesis of some new benzochromens, benzochromenopyrimidines, benzochromenotriazolopyrimidines, benzochromenopyrimidotriazepine and antimicrobial activities

“…Moreover azo compounds are known for their antineoplastics [13], antidiabetics [14], antiseptics [15], antibacterial [16] and antitumor [17]. Benzochromene represent a class of heterocyclic compounds endowed with potent antimicrobial agents [18][19][20][21][22][23], antileishmanial [24,25], anticancer [26,27], antiproliferative [28], antioxidant [29,30], hypertensive [31], antitumor [32][33][34][35] effects and activities, as well as for the treatment of Alzheimer's disease [36], schizophrenia disorders [37], and fused chromene ring systems also displayed blood platelet antiaggregating [38], antihistaminic [39], analgesic [40][41][42], hypolipidemic [43], DNA breaking and mutagenicity activities [44].…”