ChemInform Abstract: Synthesis and Reactivity of 2‐Pyrrolidino‐, 2‐N‐Methylpiperazino‐, 2‐Piperidino‐, and 2‐Morpholino‐1,3,4‐thiadiazines.

Abstract

Synthesis and Reactivity of 2-Pyrrolidino-, 2-N-Methylpiperazino-, 2-Piperidino-, and 2-Morpholino-1,3,4-thiadiazines. -A variety of the title thiadiazine derivatives (III) are synthesized by cyclocondensation of phenacyl halides with thiosemicarbazides (I). Heating of these 1,3,4-thiadiazines results in desulfurization and formation of pyrazoles. -(KNAK, S.; PFEIFFER, W.-D.; DOLLINGER, H.; LANGER*, P.; J. Heterocycl. Chem. 52 (2015) 2, 450-462, http://dx.