1995
DOI: 10.1002/chin.199527107
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ChemInform Abstract: Synthesis and Resolution of β‐(Aminomethyl)‐4‐ chlorobenzeneethanesulfinic Acid ‐ a Potent GABAB Receptor Ligand.

Abstract: 1995 sulfenic acids, sulfinic acids sulfenic acids, sulfinic acids (acyclic compounds) P 0420 -107Synthesis and Resolution of β-(Aminomethyl)-4-chlorobenzeneethanesulfinic Acid -a Potent GABAB Receptor Ligand.-The title compound (IV) is prepared in racemic form from the known GABAreceptor antagonist saclofen (I). Its resolution succeeds via the corresponding O-benzyl-protected N-hydroxysulfonamides using a Chiralcel OD column. GABA-receptor binding studies show that the (-)-enantiomer exhibits a higher biologi… Show more

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