Abstract:1995 sulfenic acids, sulfinic acids sulfenic acids, sulfinic acids (acyclic compounds) P 0420
-107Synthesis and Resolution of β-(Aminomethyl)-4-chlorobenzeneethanesulfinic Acid -a Potent GABAB Receptor Ligand.-The title compound (IV) is prepared in racemic form from the known GABAreceptor antagonist saclofen (I). Its resolution succeeds via the corresponding O-benzyl-protected N-hydroxysulfonamides using a Chiralcel OD column. GABA-receptor binding studies show that the (-)-enantiomer exhibits a higher biologi… Show more
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