ChemInform Abstract: Synthesis and SAR of New 4‐(N‐Alkyl‐N‐phenyl)amino‐6,7‐ dimethoxyquinazolines and 4‐(N‐Alkyl‐N‐phenyl)aminopyrazolo(3,4‐d) pyrimidines, Inhibitors of CSF‐1R Tyrosine Kinase Activity

Abstract

Synthesis and SAR of New 4-(N-Alkyl-N-phenyl)amino-6,7dimethoxyquinazolines and 4-(N-Alkyl-N-phenyl)aminopyrazolo(3,4d) pyrimidines, Inhibitors of CSF-1R Tyrosine Kinase Activity -(identification of several new and selective inhibitors of cell-free CSF-1R tyrosine kinase activity (cf. (I), (II), (III)); ascertainment of compound (IIb) as the most potent and selective sample in this series). -(MYERS, M. R.; SETZER, N. N.; SPADA, A. P.; PERSONS, P. E.; LY, C. Q.; MAGUIRE, M. P.; ZULLI, A. L.; CHENEY, D. L.; ZILBERSTEIN, A.; JOHNSON, S. E.; FRANKS, C. F.; MITCHELL, K. J.; Bioorg. Med. Chem. Lett. 7 (1997) 4, 421-424; Dep. Med.