ChemInform Abstract: Synthesis and Steric Structures of 3,4‐Disubstituted 1,6,7,11b‐Tetrahydropyrimido(6,1‐a)isoquinolin‐2‐ones.

Abstract

ChemInform Abstract 1-Hydrazinomethyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (I) reacts with equimolar amounts of the aromatic aldehydes (II) to give the hydrazones (III). With an excess of (II), a stereospecific ring closure reaction leading to the formation of the pyrimido(6,1-a)isoquinolines (IV) is observed.