ChemInform Abstract: Synthesis and Structure of 2‐N,N‐Dimethyl‐ and 2‐N,N‐Diethylsulfamoyl‐1‐(3‐indolyl)‐1,2‐dihydroisoquinolines.

Abstract

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Synthesis of Indole-Dihydroisoquinoline Sulfonyl Ureas via Three-Component Reactions

“…Also, benzene was used as the solvent, which we wished to avoid due to its toxicity. A later paper from Skrypnik 7 reported two compounds containing our desired motif 1, using sulfamoyl chlorides as the activating species. The scope was limited, however, with no substitution on the isoquinoline or indole and only Me and Et sulfamoyl chlorides.…”

Sulfamic Acid and Its N- and O-Substituted Derivatives

“…The sulfamide 91 formed when dimethylsulfamoyl chloride was reacted with 2- tert -butyl-1-(cyclohexylmethyl)- N -methyl-1 H -benzimidazol-5-ylamine . R 2 NSO 2 Cl (R = Me, Et) reacts with isoquinoline and indole to give a sulfamide that combines the isoquinoline and indole rings . Two Japanese patents , described the use of dimethyl- and bis-dimethylsulfamoyl chlorides in reaction with substituted triazoles to prepare fungicides that incorporate the triazole ring(s).…”