ChemInform Abstract: Synthesis and Structure of 5‐Alkyl(aryl)pyrrol‐2‐ones.

Abstract

Synthesis and Structure of 5-Alkyl(aryl)pyrrol-2-ones. -Amination of 4-oxoalkanoic acids or their esters leads to the title pyrrolones (II), which exist in solution as a mixture of cyclic and open-chain isomers in ratios depending on the nature of the substituent at 5-position of the heterocycle. -(EGOROVA, A. YU.; SEDAVKINA, V. A.; TIMOFEEVA, Z. YU.; Chem. Heterocycl.

Investigation of N-Aryl-3-alkylidenepyrrolinones as Potential Niemann−Pick Type C Disease Therapeutics

“…In addition to providing a series of analogues, a synthesis of pure compounds would minimize the risk of false positives in further assays. A survey of the literature revealed that there have been previous reports of the synthesis of the core 3-alkylidene-4-pyrrolin-2-one scaffold 10. Many of these routes utilize 3-alkylidene-furan-2-ones as starting materials 10a,10d,11.…”