ChemInform Abstract: Synthesis and Structure—Activity Relationships of Thiotetronic Acid Analogues of Thiolactomycin.

Abstract

Synthesis and Structure-Activity Relationships of Thiotetronic Acid Analogues of Thiolactomycin.-Synthetic efforts to improve the antibacterial activity of thiolactomycin (VI), a thiotetronic acid natural product, via semisynthetic modifications of thiolactomycin [→(XI), (XII)] and 3-acetylthiotetronic acid analogues [→(III), (V)] are described. Some analogues show improved activity over thiolactomycin against Staphylococcus aureus and comparable activity against Pasteurella multocida. -(SAKYA, SUBAS M.; SUAREZ-CONTRERAS, MELANI; DIRLAM, JOHN P.; O'CONNELL, THOMAS N.; HAYASHI, SHIGERU F.; SANTORO, SHERYL L.; KAM-ICKER, BARBARA J.; GEORGE, DAVID M.; ZIEGLER, CARL B.; Bioorg.