ChemInform Abstract: Synthesis and Structure—Activity Relationships in a Series of Ethenesulfonamide Derivatives, a Novel Class of Endothelin Receptor Antagonists.

Abstract

Synthesis and Structure-Activity Relationships in a Series of Ethenesulfonamide Derivatives, a Novel Class of Endothelin ReceptorAntagonists.-Compound (IIb) is an ET A selective antagonist with an oral endothelin selective antagonistic activity in rats. -(HARADA, HI-