ChemInform Abstract: Synthesis and Testing of Quinone‐Based Bis(2,2‐dimethyl‐1‐aziridinyl)phosphoryl Carbamates as Radiation‐Potentiating Antitumor Agents.

Abstract

268ChemInform Abstract Chloranil (I) is coupled with two equivalents of 2-aminoethanol (II) to give the benzoquinone (III) which consecutively reacts with the isocyanate (IV) and 2,2-dimethylaziridine (V) to form the bis(carbamates) (VI). The hydroxymethylanthraquinone (VII) is treated analogously with (IV) and (V), yielding the carbamate (VIII). The activity of (VI) against P-388 leukemia is tested in female mice. The ability of (VI) and (VIII) to potentiate the cytotoxic effect of X-irradiation is also investigated.