ChemInform Abstract: Synthesis and Transformation of Methyl 2‐(6‐Hydroxy‐2‐phenylpyrimidin‐4‐yl)acetate: Simple Preparation of Pyrimidines with Heterocyclic Substituents.

Abstract

A simple method for the synthesis of title compound (III) is presented. Further reaction with N,N-dimethylformamide dimethylacetal gives the (E)-configurated propenoate (V) as starting material for condensation reactions with various dinucleophiles. According to the enaminone methodology, four new substituted pyrimidines are obtained with satisfactory yields. -(BEVK, D.; GROSELJ, U.; MEDEN, A.; SVETE, J.; STANOVNIK*, B.; Helv.