ChemInform Abstract: Synthesis, Characterization and Antibacterial Screening of New Pyrazole (VI) and Pyrazoline‐5‐one Derivatives (III).

Nagaraju, V.; Ramineni, Srinivasulu; Doraswamy, K.; Ramana, P. Venkata

doi:10.1002/chin.201203106

Cited by 2 publications

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“…A solution of sodium acetate (100 g) in 100 mL aqueous alcohol (50%) was added to a solution of ethyl acetoacetate (100 g) in 500 mL of ethanol and the mixture was cooled. To this cold mixture, the corresponding diazonium chloride (5) was added gradually till turbidity was observed 6 . The addition was continued till yellow crystals separated out.…”

Section: General Procedures For the Synthesis Of Compounds (7a-h)mentioning

confidence: 99%

“…Pyrazoles have a unique place and contributed significantly to biological, medicine, pharmacology fields. Pyrazole ring containing substituted five membered ring exhibited antibacterial, antifungal, tumor-necrosis inhibitor, antimicrobial, hypoglycemic, hypolipidemic and anti-inflammatory activity [5][6][7][8][9][10][11][12][13][14][15] . On the other hand quinoline and their…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of New Pyrazole Derivatives Containing 2-Methylquinoline Ring System: A Novel Class of Potential Antimicrobial Agents

2016

Chem Sci Trans

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Two series of diversely substituted 1-(3,5-dimethyl-4-(substitutedphenyldiazenyl)-1Hpyrazol-1-yl)-2-((2-methylquinolin-8-yl)oxy)ethanones (8a-g) and 3-methyl-1-(2-((2-methylquinolin-8-yl)oxy)acetyl)-4-(2-substitutedphenylhydrazono)-1H-pyrazol-5(4H)-ones (9a-h) were synthesized. All the newly synthesized compounds were characterized by IR, 1 H NMR, 13 C NMR, Mass and chemical analysis. The compounds were evaluated for their in vitro antibacterial activity against some Gram-positive bacteria, Staphylococcus aureus, Bacillus subtilis, Gram-negative bacteria, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi and screened for antifungal activity against Aspergillus niger, Ustilago maydis using the agar disc diffusion method. All the tested compounds showed significant antibacterial activity against both the strains with compounds 8d and 9d being more potent.

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Section: General Procedures For the Synthesis Of Compounds (7a-h)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis of New Pyrazole Derivatives Containing 2-Methylquinoline Ring System: A Novel Class of Potential Antimicrobial Agents

2016

Chem Sci Trans

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“…The diazotized aromatic amines when condensed at active methylene position of ethyl aceto acetate, give 2-(substituted arylhydrazono)-ethyl-2,3-dioxobutyrates. The latter on cyclization with ptoluenesulphonyl hydrazide give N'-(p-toluenesulphonyl)-3-methyl-4-(4'-substituted arylhydrazono)pyrazolin-5-ones 5 (1)(2)(3)(4)(5).…”

Section: Synthesis Of N'-(p-toluenesulphonyl)-3-methyl-4-(4'-substitumentioning

confidence: 99%

Electrochemical Behaviour of N′‐(p‐toluenesulphonyl)‐3‐methyl‐4‐(4′‐substituted arylhydrazono) pyrazolin‐5‐ones

Nagaraju

Sreenivasulu

Ramana

2011

Journal of Chemistry

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The electrochemical behaviour of N′-(p-toluenesulphonyl)-3-methyl-4-(4′-substituted arylhydrazono) pyrazolin-5-ones has been investigated at dme and gc electrodes in buffer solutions of pH 2.0, 4.0, 6.0, 8.0 and 10.0 using dc polarography and cyclic voltammetry and coulometry. The compounds exhibit one well defined wave in the entire pH range of study. The process is irreversible and diffusion controlled. Controlled potential electrolysis indicates the involvement of four electrons in the reduction process. The effect of solvent, cations and anions, temperature and substitutents on the mechanism of reduction has been studied. Based on the results obtained the mechanism of reduction has been suggested.

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ChemInform Abstract: Synthesis, Characterization and Antibacterial Screening of New Pyrazole (VI) and Pyrazoline‐5‐one Derivatives (III).

Abstract: ). -Compounds (IIId-f) and (VIf) exhibit moderate to good antibacterial activities against S. aureus and E. coli. -(NAGARAJU, V.; SRINIVASULU, R.; DORASWAMY, K.; RAMANA*, P. V.; J.

Cited by 2 publications

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Synthesis of New Pyrazole Derivatives Containing 2-Methylquinoline Ring System: A Novel Class of Potential Antimicrobial Agents

Synthesis of New Pyrazole Derivatives Containing 2-Methylquinoline Ring System: A Novel Class of Potential Antimicrobial Agents

Electrochemical Behaviour of N′‐(p‐toluenesulphonyl)‐3‐methyl‐4‐(4′‐substituted arylhydrazono) pyrazolin‐5‐ones

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