ChemInform Abstract: Synthesis, Characterization, in vitro and Molecular Docking Studies of New 2,5‐Dichloro Thienyl Substituted Thiazole Derivatives for Antimicrobial Properties.

Abstract

Synthesis, Characterization, in vitro and Molecular Docking Studies of New 2,5-Dichloro Thienyl Substituted Thiazole Derivatives for Antimicrobial Properties. -The new compounds (IV), containing a dichlorothienyl-substituted thiazole ring system, which resemble a known antifungal agent are screened for antifungal and antibacterial activities. Derivative (IVe) is the most active one against all tested microorganisms, and molecular docking studies reveal that (IVe) has minimum binding and docking energy and may be considered as a good inhibitor of GlcN-6-P synthase. -(SAROJINI*, B. K.; KRISHNA, B. G.; DARSHANRAJ, C. G.; BHARATH, B. R.; MANJUNATHA, H.; Eur.