ChemInform Abstract: Synthetic Studies on MPC1001: A Dipolar Cycloaddition Approach to the Pyrrolidine Ring System.

Abstract

The approach towards the total synthesis of MPC1001 is based on disconnections across the dioxopiperazine and the diaryl ether subunit of MPC1001 utilizing a late‐stage construction of the oxepin ring via the highly substituted pyrrolidine (IV), which in turn is accessible by a novel asymmetric dipolar cycloaddition methodology involving substrates (I), (II), and (III).