ChemInform Abstract: Taxuspines A ‐ C, New Taxoids from Japanese Yew Taxus cuspidata Inhibiting Drug Transport Activity of P‐Glycoprotein in Multidrug‐ Resistant Cells.

Abstract

The structures of the title compounds (I)-(III), which are isolated together with nine known taxoids, are confirmed by spectroscopic means and photochemical synthesis. They increase vincristine accumulation in multidrug-resistant tumor cells and show weak cytotoxicity. (II) also reduces CaCl2-induced depolymerization of microtubules. -(KOBAYASHI, J.; OGIWARA, A.; HOSOYAMA, H.; SHIGEMORI, H.; YOSHIDA, N.; SASAKI, T.; LI, Y.; IWASAKI, S.; NAITO, M.; TSURUO, T.; Tetrahedron 50 (1994) 25, 7401-7416; Fac. Pharm. Sci., Hokkaido Univ., Sapporo 060, Japan; EN)