ChemInform Abstract: The Cytotoxic Action of 1,3,5‐Triazabicyclo[3.1.0]hexane‐2,4‐diones and 1,3,5‐Triazine‐4,6‐(1H,5H)‐diones in Murine and Human Tumor Cells.

Abstract

1998 pharmacology, medicinal chemistry, vaccines, serums pharmacology, medicinal chemistry, vaccines, serums V 1100 44 -284 The Cytotoxic Action of 1,3,5-Triazabicyclo[3.1.0]hexane-2,4-diones and 1,3,5-Triazine-4,6-(1H,5H)-diones in Murine and Human Tumor Cells. -A number of the tested title compounds like (I) and (II), prepared by literature methods, are found to be potent cytotoxic and antineoplastic agents, cf. derivatives (Ia)-(Ic). -(HALL, I. H.; TAYLOR, K.; IZYDORE, R. A.; COLEMAN, D. E.; MITCHELL, J. A.; CUMMINGS, R.; Pharmazie 53

Degradation Pathways of a Corticotropin-Releasing Factor Antagonist in Solution and Solid States

“…Despite the fact that many of investigational and approved medicinal agents are 1,3,5‐triazine derivatives, there are little published reports on stability of those agents, particularly in the solid state 3–8. Moreover, there are no reports in the pharmaceutical literature regarding degradation profile of any pyrazolo‐[1,5‐a]‐1,3,5‐triazine derivatives.…”