ChemInform Abstract: The Directed ortho Metalation — Cross‐Coupling Symbiosis in Heteroaromatic Synthesis

Abstract

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The Crystal and Molecular Structure of (2Z)-2-[3-(4-Methoxybenzoyl)-4,4-dimethyl-1,2-oxazolidin-2-ylidene]-1-(4-methoxyphenyl)ethanone

“…The 2-oxazolines, a sub-class of the azoles, consist of a 5-membered ring system consisting of one O-and one N-atom separated by a single carbon; these latter two atoms being formally sp 2 hybridised [1,2]. The group itself represents an important heterocyclic functionality as these molecules are routinely used as ligands in coordination chemistry [3][4][5][6] and catalysis [7][8][9][10], as directing groups in chemical modification strategies [11][12][13][14] and as a protecting group for carboxylic acids [15][16][17][18]. The ring is also found in a number of natural products, many of which have been the subject of total synthesis.…”

The Crystal and Molecular Structure of (2Z)-2-[3-(4-Methoxybenzoyl)-4,4-dimethyl-1,2-oxazolidin-2-ylidene]-1-(4-methoxyphenyl)ethanone

“…The 2-oxazolines, a sub-class of the azoles, consist of a 5-membered ring system consisting of one O-and one N-atom separated by a single carbon; these latter two atoms being formally sp 2 hybridised [1,2]. The group itself represents an important heterocyclic functionality as these molecules are routinely used as ligands in coordination chemistry [3][4][5][6] and catalysis [7][8][9][10], as directing groups in chemical modification strategies [11][12][13][14] and as a protecting group for carboxylic acids [15][16][17][18]. The ring is also found in a number of natural products, many of which have been the subject of total synthesis.…”

The Crystal and Molecular Structure of (2Z)-2-[3-(4-Methoxybenzoyl)-4,4-dimethyl-1,2-oxazolidin-2-ylidene]-1-(4-methoxyphenyl)ethanone

“…The group itself represents an important heterocyclic functionality as these molecules are routinely used as ligands in coordination chemistry [3][4][5][6] and catalysis [7][8][9][10], as directing groups in chemical modification strategies [11][12][13][14] and as a protecting group for carboxylic acids [15][16][17][18]. The ring is also found in a number of natural products, many of which have been the subject of total synthesis.…”