ChemInform Abstract: The Ugi Reaction of Cyanoacetic Acid as a Route to Tetramic Acid Derivatives.

Abstract

The Ugi Reaction of Cyanoacetic Acid as a Route to Tetramic Acid Derivatives. -The Ugi one-pot reaction of cyanoacetic acid (I), aromatic aldehydes [e.g. (III)], amines [e.g. (II)], and isocyanides [e.g. (IV)] produces aminopyrrolinone derivatives [e.g. (V)]. This reaction doesn't apply to aliphatic aldehydes. -(ALVAREZ-RODRIGUEZ, N. V.; DOS SANTOS, A.; EL KAIM*, L.; GAMEZ-MONTANO, R.; Synlett 26 (2015) 16, 2253-2256, http://dx.doi.org/10.1055/s-0035-1560050 ; Lab. D.C.S.O., CNRS, Ec. Polytech., F-91128 Palaiseau, Fr.; Eng.) -L. Grundl 08-130