ChemInform Abstract: Thiol‐Ene “Click” Reaction Triggered by Neutral Ionic Liquid: The “Ambiphilic” Character of [hmim]Br in the Regioselective Nucleophilic Hydrothiolation.

An efficient and eco-friendly synthesis of 1, 4-dihydropyridines via Hantzsch reaction in Glycine-HCl buffer as solvent and bio-catalyst

“…Tamaddon and co-worker reported 24 the synthesis of 1,4-dihydropyridines using ammonium carbonate with high yield at long reaction times. Also, Kumar and co-worker presented 25 catalytic efficiency of glycine nitrate (GlyNO3) ionic liquid under microwave (MW) irradiation for the synthesis of symmetrical and unsymmetrical 1,4-DHPs, in which the yield of the reaction in the water was very low. We herein introduce a convenient, inexpensive and efficient synthetic method in glycine-HCl buffer as a solvent and biocatalyst.…”

Synthesis of Stable Isotope Labeled 13C4-1,4-Dihydropyridines on 5,6-Position and Its Substituent Carbon

“…1.1 13 C 4 -乙酰乙酸酯的合成讨论 当前报道的 13 C 标记的乙酰乙酸酯的合成方法有克 莱森缩合法(Scheme 2, A) [21][22] 、克莱森缩合改进法 (Scheme 2, B) [23] 、丙二酸法(Scheme 2, C) [24] 、双烯酮法 (Scheme 2, D) [19] 以及乙酰咪唑的克莱森缩合酯化法 (Scheme 2, E) [20] . 克莱森缩合法和丙二酸法产率较低, 仅为 65%; 双烯酮法受到 13 [25] 、醋酸铵 [26][27] 、氨水 [28][29][30] 、 碳酸铵 [31] 、碳酸氢铵 [32] 、氨基甲酸铵 [33] 等. 而氨气、醋 酸铵、氨水、碳酸铵和碳酸氢铵应用存在一个或多个缺 点, 例如长时间加热, 过量使用氨或铵盐, 产率不尽如 人意以及反应混合物萃取后处理的必要性.…”

Markovnikov Selective Hydroboration of Aryl Alkenes Catalyzed by Quaternary Ammonium Salts

“…In recent years, quaternary ammonium salts (QASs) have been used as solvents and immobilization media for TM-catalysts but they have garnered significant attention as organocatalysts for the hydrofunctionalization of unsaturated C-C bonds. [32][33][34][35][36][37] We previously reported an ionic liquid-catalyzed anti-Markovnikov selective hydroboration of alkenes (Figure 1b). 38 In the current work, we investigated QASs as catalysts for hydroboration of alkenes leading to Markovnikov organoboranes (Figure 1c).…”