ChemInform Abstract: Three New Chalcones from the Aerial Parts of Angelica keiskei

Abstract

isolation and structure elucidation of three new chalcones (I), (II), and (III)

Angelica keiskei, an emerging medicinal herb with various bioactive constituents and biological activities

“…In our recent study on the aerial parts of A. keiskei, eight constituents, 4,2 0 ,4 0 -trihydroxy-3 0 -[(2E,5E)-7-methoxy-3,7-dimethyl-2,5-octadienyl]chalcone (32), (±)-4,2 0 ,4 0 -trihydroxy-3 0 -[(2E)-6-hydroxy-7-methoxy-3,7-dimethyl-2-octenyl]chalcone (33), 4,2 0 ,4 0 -trihydroxy-3 0 -[(2E)-3-methyl-5-(1,3-dioxolan-2-yl)-2-pentenyl] chalcone (34), 2 0 ,3 0 -furano-4-hydroxy-4 0 -methoxychalcone (35), (±)-4-hydroxy-2 0 ,3 0 -(2,3-dihydro-2-methoxyfurano)-4 0 -methoxychalcone (36), 3 0 -carboxymethyl-4,2 0 -dihydroxy-4 0 -methoxychalcone (37), (±)-4,2 0 ,4 0 -trihydroxy-3 0 -[(3-hydroxy-2,2-dimethyl-6-methylenecyclohexyl)methyl] chalcone (38), and 2 00 -hydroxyangelichalcone (39) were isolated and reported as new compounds from an ethyl acetate extract along with eight known compounds, xanthoangelol (1), xanthoangelol F (2), 4-hydroxyderricin (3), xanthoangelol G (6), xanthoangelol D (9), xanthoangelol E (10), xanthoangelol H (12), (±)-4,2 0 ,4 0 -trihydroxy-3 0 -[(6E)-2-hydroxy-7-methyl-3-methylene-6-octenyl]chalcone (27), artocarmitin A (40), (? )-cis-(3 0 R,4 0 R)-methylkhellactone (93), (-)-trans-(3 0 R,4 0 S)-methylkhellactone (94), 3,4-dihydroxanthotoxin (95), and (Z)-p-coumaryl alcohol (97) (Kil et al 2015a(Kil et al , 2016. In particular, xanthoangelol (1) and 4-hydroderricin (3) were isolated in bulk (1: 5 g, 2: 1.8 g), which supported that the two chalcones are the predominant constituents in this herb.…”