ChemInform Abstract: Various Approaches for the Synthesis of 1,2‐Dideoxy‐β‐aryl or Heteroaryl‐D‐ribo‐furanose Frameworks

Abstract

Organic chemistry Z 0200Various Approaches for the Synthesis of 1,2-Dideoxy-β-aryl or Heteroaryl-D-ribo-furanose Frameworks -[81 refs.]. -(MAHALINGAM, S. M.; MANJUNATH, B. N.; AIDHEN, I. S.; Proc. Indian Natl. Sci. Academy, Part A: Phys. Sci. 71 (2005) 3-4, 267-282; Dep. Chem., Indian Inst. Technol., Chennai 600 036, India; Eng.) -Lindner 23-247

Efficient synthesis of fluorescent alkynyl C-nucleosides via Sonogashira coupling for the preparation of DNA-based polyfluorophores

“…To date, the fluorescent monomers for the synthesis of ODFs were mainly obtained by nucleophilic substitution of Hoffer’s chlorosugar 23 with different metallated aromatic dyes. 24 In that strategy, the fluorophores are directly attached to the anomeric carbon atom of the sugar. However, major drawbacks of that approach are the relatively low coupling yields, 25 the limited functional group compatibility, and the generation of mixtures of α- and β-anomers, which in some cases can be difficult to separate.…”