ChemInform Abstract: Water Mediated Construction of Trisubstituted Pyrazoles/Isoxazoles Library Using Ketene Dithioacetals.

Abstract

A solution-phase library of the title compounds (V) and (VIII) with methyl, sulfone and carboxamide moieties is prepared by a two-step synthesis starting from (IV) using water as a green solvent. -(SAVANT, M. M.; PANSURIYA, A. M.; BHUVA, C. V.; KAPURIYA, N.; PATEL, A. S.; AUDICHYA, V. B.; PIPALIYA, P. V.; NALIAPARA*, Y. T.; J.

One-Pot Sequential Approach for the Construction of Highly Functionalized Triazolo[4,3-c]pyrimidine Library

“…Visualization was made with UV light (254 and 365nm) or with an iodine vapor. 1 H NMR were recorded on a 400 MHz and 13 C NMR were recorded on a 100 MHz instrument using CDCl 3 and DMSO-d 6 as a solvent on a Bruker AVANCE II spectrometer. Chemical shifts are reported in parts per million relative to tetramethylsilane using the residual solvent signal as the internal reference.…”

“…- [1,2,4]triazolo [4,3-c] 165. 25, 161.22, 160.73, 160.62, 151.52, 148.03, 146.94, 136.19, 134.11, 131.30, 131.00, 129.59, 123.29, 120.86, 119.59, 114.75, 113.50, 109.04, 70.16, 55.41, 31.39, 21.94, 21.85, 21. 5-(4-isopropoxyphenyl)-7-isopropyl-N, 3-di-p-tolyl-[1,2,4]triazolo [4,3-c] 77, 164.70, 163.17, 161.28, 157.46, 135.36, 134.71, 130.83, 129.91, 128.45, 125.51, 120.53, 115.66, 70.16, 34.02, 22.19, 21.14 , 6.40; N, 13.48;found: C, 73.34; H, 6.72; N, 13.93.…”

“…25, 161.22, 160.73, 160.62, 151.52, 148.03, 146.94, 136.19, 134.11, 131.30, 131.00, 129.59, 123.29, 120.86, 119.59, 114.75, 113.50, 109.04, 70.16, 55.41, 31.39, 21.94, 21.85, 21. 5-(4-isopropoxyphenyl)-7-isopropyl-N, 3-di-p-tolyl-[1,2,4]triazolo [4,3-c] 77, 164.70, 163.17, 161.28, 157.46, 135.36, 134.71, 130.83, 129.91, 128.45, 125.51, 120.53, 115.66, 70.16, 34.02, 22.19, 21.14 , 6.40; N, 13.48;found: C, 73.34; H, 6.72; N, 13.93. 3-(2,5-dimethoxyphenyl)-5-(4-isopropoxyphenyl)-7isopropyl-N-(p-tolyl)- [1,2,4]triazolo [4,3-c] 39, 161.35, 160.32, 153.70, 151.67, 150.06, 148.79, 144.48, 136.24, 134.10, 130.35, 129.60, 123.49, 120.91, 117.87, 117.38, 115.63, 113.92, 110.77, 109.09, 70.17, 56.26, 54.98, 31.46, 22.84, 22.15, 21.86, 21.15, 21. , 6.24; N, 12.38; found: C, 71.64; H, 5.88; N, 12.06. (3-bromophenyl)-5-(4-isopropoxyphenyl)-7isopropyl-N-(p-tolyl)- [1,2,4]triazolo [4,3-c] (400 MHz,160.98,151.89,147.80,145.60,136.06,134.25,132.77,132.68,131.03,129.62,129.04,128.10,123.11,121.91,120.89,114.97,109.29,70.36,31.48,21.01,21.94,21.15 5.17; N, 11.98; found: C, 63.92; H, 5.28; N, 12.24.…”

“…3-(2,5-dimethoxyphenyl)-5-(4-isopropoxyphenyl)-7isopropyl-N-(p-tolyl)- [1,2,4]triazolo [4,3-c] 39, 161.35, 160.32, 153.70, 151.67, 150.06, 148.79, 144.48, 136.24, 134.10, 130.35, 129.60, 123.49, 120.91, 117.87, 117.38, 115.63, 113.92, 110.77, 109.09, 70.17, 56.26, 54.98, 31.46, 22.84, 22.15, 21.86, 21.15, 21. , 6.24; N, 12.38; found: C, 71.64; H, 5.88; N, 12.06. (3-bromophenyl)-5-(4-isopropoxyphenyl)-7isopropyl-N-(p-tolyl)- [1,2,4]triazolo [4,3-c] (400 MHz,160.98,151.89,147.80,145.60,136.06,134.25,132.77,132.68,131.03,129.62,129.04,128.10,123.11,121.91,120.89,114.97,109.29,70.36,31.48,21.01,21.94,21.15 5.17; N, 11.98; found: C, 63.92; H, 5.28; N, 12.24. 3-(4-cyanophenyl)-5-(4-isopropoxyphenyl)-7isopropyl-N-(p-tolyl)- [1,2,4]triazolo [4,3-c] 165.95, 164.82, 163.96, 162.34, 151.14, 148.90, 138.48, 137.65, 134.29, 133.76, 133.10, 132.25, 132.16, 130.08, 126.10, 122.72, 121.48, 121.03, 118.79, 115.44, 32.44, 21.89, 20.16, 19.43…”

“…(3-bromophenyl)-5-(4-isopropoxyphenyl)-7isopropyl-N-(p-tolyl)- [1,2,4]triazolo [4,3-c] (400 MHz,160.98,151.89,147.80,145.60,136.06,134.25,132.77,132.68,131.03,129.62,129.04,128.10,123.11,121.91,120.89,114.97,109.29,70.36,31.48,21.01,21.94,21.15 5.17; N, 11.98; found: C, 63.92; H, 5.28; N, 12.24. 3-(4-cyanophenyl)-5-(4-isopropoxyphenyl)-7isopropyl-N-(p-tolyl)- [1,2,4]triazolo [4,3-c] 165.95, 164.82, 163.96, 162.34, 151.14, 148.90, 138.48, 137.65, 134.29, 133.76, 133.10, 132.25, 132.16, 130.08, 126.10, 122.72, 121.48, 121.03, 118.79, 115.44, 32.44, 21.89, 20.16, 19.43…”