1962
DOI: 10.1038/1951264a0
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Chemistry, Toxicology, Pharmacology and Microbiology of a new Acid-Stable Penicillin, Resistant to Penicillinase (BRL.1621)

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Cited by 47 publications
(25 citation statements)
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“…Cloxacillin and flucloxacillin have been evaluated with penicillinase positive S. aureus in mind; these are usually sensitive to 0.5 /rg/ml [16,24], Flucloxacillin is marginally more active than cloxacillin [24], It may be an advantage that flucloxacillin also has a slightly lower serum protein binding [19,24], Flucloxacillin is preferable also pharmacokinetically since cloxa cillin might have to be given up to 6 times daily to render sufficiently high Cmin levels, whereas only 4 dosages are necessary with flucloxacillin.…”
Section: Cross-over Study O F Penicillin Pharmacokinetics After Intramentioning
confidence: 99%
“…Cloxacillin and flucloxacillin have been evaluated with penicillinase positive S. aureus in mind; these are usually sensitive to 0.5 /rg/ml [16,24], Flucloxacillin is marginally more active than cloxacillin [24], It may be an advantage that flucloxacillin also has a slightly lower serum protein binding [19,24], Flucloxacillin is preferable also pharmacokinetically since cloxa cillin might have to be given up to 6 times daily to render sufficiently high Cmin levels, whereas only 4 dosages are necessary with flucloxacillin.…”
Section: Cross-over Study O F Penicillin Pharmacokinetics After Intramentioning
confidence: 99%
“…ROLINSON and BATCHELOR (1962) showed one active metabolite by bioautography against Bacillus subtilis while ROLLO et al (1962) reported two metabolites accounting for 20% of the urinary activity against Sarcina lutea.…”
Section: Pbenbenicillinmentioning
confidence: 95%
“…Also present in urine is another metabolite that is biologically active, more polar than the parent, and thought to be hydroxylated pheneticillin (ROLINSON and BATCHELOR 1962;VANDERHAEGHE et al 1963).…”
Section: Pheneticillinmentioning
confidence: 99%
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