Chemo-bio catalysis using carbon supports: application in H<sub>2</sub>-driven cofactor recycling

Zhao, Xu; Cleary, Sarah; Zor, Ceren; Grobert, Nicole; Reeve, Holly A.; Vincent, Kylie A.

doi:10.1039/d1sc00295c

Cited by 16 publications

(16 citation statements)

References 48 publications

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“…These inorganic functionalized electrodes are in big competition with enzymatic systems where electrodes surfaces are modified with electrocatalytic enzymes (e.g., NAD + reductase for NADH regeneration, ferredoxin NADP + reductase for NADPH regeneration), and hydrogenase for hydrogen production and oxidation . The choice between inorganic and enzymatic systems depends on the activity, stability, and economic viability of the process in which the catalyst is applied.…”

Section: Recent Examples About the Application Of Electroanalytical T...mentioning

confidence: 99%

Advanced Electroanalysis for Electrosynthesis

Brachi,

El Housseini,

Beaver

et al. 2023

ACS Org. Inorg. Au

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Electrosynthesis is a popular, environmentally friendly substitute for conventional organic methods. It involves using charge transfer to stimulate chemical reactions through the application of a potential or current between two electrodes. In addition to electrode materials and the type of reactor employed, the strategies for controlling potential and current have an impact on the yields, product distribution, and reaction mechanism. In this Review, recent advances related to electroanalysis applied in electrosynthesis were discussed. The first part of this study acts as a guide that emphasizes the foundations of electrosynthesis. These essentials include instrumentation, electrode selection, cell design, and electrosynthesis methodologies. Then, advances in electroanalytical techniques applied in organic, enzymatic, and microbial electrosynthesis are illustrated with specific cases studied in recent literature. To conclude, a discussion of future possibilities that intend to advance the academic and industrial areas is presented.

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Section: Recent Examples About the Application Of Electroanalytical T...mentioning

confidence: 99%

Advanced Electroanalysis for Electrosynthesis

Brachi,

El Housseini,

Beaver

et al. 2023

ACS Org. Inorg. Au

View full text Add to dashboard Cite

show abstract

“…The most popular enzyme systems right now are glucose-dehydrogenase (Sorgedrager et al, 2008;Liang et al, 2010b;Huisman et al, 2010;Gong et al, 2017;Chen et al, 2021) and formate dehydrogenase (Shaked and Whitesides, 1980;Seelbach et al, 1996;Gröger et al, 2004;Jiang et al, 2020). Very recently, Vincent and coworkers reported significant advances in the use of hydrogenases (Reeve et al, 2012;Reeve et al, 2017;Zor et al, 2017;Zhao et al, 2021) enabling H 2 as cosubstrates.…”

Section: Regeneration Of Reduced Nicotinamide Cofactorsmentioning

confidence: 99%

Alcohol Dehydrogenases as Catalysts in Organic Synthesis

2022

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Alcohol dehydrogenases (ADHs) have become important catalysts for stereoselective oxidation and reduction reactions of alcohols, aldehydes and ketones. The aim of this contribution is to provide the reader with a timely update on the state-of-the-art of ADH-catalysis. Mechanistic basics are presented together with practical information about the use of ADHs. Current concepts of ADH engineering and ADH reactions are critically discussed. Finally, this contribution highlights some prominent examples and future-pointing concepts.

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“…Vincent and co-authors reported the chem-bio catalyzed H 2 -driven NADH regeneration with reductase governing NAD + reduction. [6] In addition to enzymes, organometallic complexes and metal nanoparticles (NPs) are the most widely used hydrogenation catalysts. [7] However, they confront big challenges in H 2 -driven NAD(P) + reduction.…”

Section: Introductionmentioning

confidence: 99%

Enzyme‐Compatible Core‐Shell Nanoreactor for in Situ H₂‐Driven NAD(P)H Regeneration

2023

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The regeneration of the reduced form cofactor NAD(P)H is essential for the extra‐cellular application of bio‐reduction, which necessitates not only the development of efficient artificial NAD(P)H regeneration catalytic system but also its well compatibility with the cascade enzymatic reduction system. In this work, we reported the preparation of a metal nanoparticle (NP) and metal complex integrated core‐shell nanoreactor for H2‐driven NAD(P)H regeneration through the immobilization of a Rh complex on Ni/TiO2 surface via a bipyridine contained 3D porous organic polymer (POP). In comparison with the corresponding single component metal NPs and the immobilized Rh complex, the integrated catalyst presented simultaneously enhanced activity and selectivity in NAD(P)H regeneration thanks to the rapid spillover of activated H species from metal NPs to Rh complex. In addition, the size‐sieving effect of POP precluded the direct interaction of enzyme and Rh complex confined in the pores, enabling the success coupling of core‐shell nanoreactor and aldehyde ketone reductase (AKR) for chemoenzymatic reduction of acetophenone to (R)‐1‐phenylethan‐1‐ol. This work provides a strategy for the rational manipulation of multicomponent cooperation catalysis.

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Chemo-bio catalysis using carbon supports: application in H₂-driven cofactor recycling

Abstract: Heterogeneous biocatalytic hydrogenation is an attractive strategy for clean, enantioselective C=X reduction. This approach relies on enzymes powered by H2-driven NADH recycling. Commercially available carbon-supported metal (metal/C) catalysts are investigated...

Cited by 16 publications

References 48 publications

Advanced Electroanalysis for Electrosynthesis

Advanced Electroanalysis for Electrosynthesis

Alcohol Dehydrogenases as Catalysts in Organic Synthesis

Enzyme‐Compatible Core‐Shell Nanoreactor for in Situ H₂‐Driven NAD(P)H Regeneration

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Chemo-bio catalysis using carbon supports: application in H2-driven cofactor recycling

Abstract: Heterogeneous biocatalytic hydrogenation is an attractive strategy for clean, enantioselective C=X reduction. This approach relies on enzymes powered by H2-driven NADH recycling. Commercially available carbon-supported metal (metal/C) catalysts are investigated...

Cited by 16 publications

References 48 publications

Advanced Electroanalysis for Electrosynthesis

Advanced Electroanalysis for Electrosynthesis

Alcohol Dehydrogenases as Catalysts in Organic Synthesis

Enzyme‐Compatible Core‐Shell Nanoreactor for in Situ H2‐Driven NAD(P)H Regeneration

Contact Info

Product

Resources

About

Chemo-bio catalysis using carbon supports: application in H₂-driven cofactor recycling

Enzyme‐Compatible Core‐Shell Nanoreactor for in Situ H₂‐Driven NAD(P)H Regeneration