Chemodiversity of Clausena excavata (Rutaceae) and related species: Coumarins and carbazoles

Wongthet, Natthawadi; Schinnerl, Johann; Valant–Vetschera, Karin M.; Bacher, Markus; Vajrodaya, Srunya

doi:10.1016/j.bse.2018.07.007

Cited by 6 publications

(4 citation statements)

References 37 publications

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“…On the other hand, Arbab et al [ 6 ] revealed that α- Pinene (12.23%) and Copaene (12.40%) were the major constituents present in the essential oil of C. harmandiana . Moreover, bioactive Carbazoles and Coumarins were observed as the major constituents of C. excavata and C. harmandiana , of which these two compounds were identified as bioactive compounds [ 11 , 25 , 26 ]. According to the results of the assessment of the essential oil of M. koenigii , it was found to possess Anethole (26.02%), Caryophyllene (21.15%) and α- Pinene (12.23%) as the major components.…”

Section: Resultsmentioning

confidence: 99%

“…In Thailand, the genus Clausena is considered an economically important group of plants with a range of potential health benefits. Specifically, C. excavata and C. harmandiana have been identified as plants within this genus that show potential in the development of natural health treatments [ 10 , 11 ]. Concerning the tribe Clauseneae, several species in this tribe have been acknowledged as sources of edible fruits, essential oils, herbal medicines, spices ( Murraya exotica and M. kwangsiensis ) and various horticultural items ( Clausena anisum-olens , C. lansium and Glycosmis parviflora ).…”

Section: Introductionmentioning

confidence: 99%

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Phytochemical Analysis and Evaluation of Antioxidant and Biological Activities of Extracts from Three Clauseneae Plants in Northern Thailand

Tanruean

Poolprasert

Suwannarach

et al. 2021

Plants

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This study established the DNA barcoding sequences (matK and rbcL) of three plant species identified in the tribe Clauseneae, namely Clausena excavata, C. harmandiana and Murraya koenigii. The total phenolic and total flavonoid contents, together with the biological activities of the derived essential oils and methanol extracts, were also investigated. Herein, the success of obtaining sequences of these plant using two different barcode genes matK and rbcL were 62.5% and 100%, respectively. Both regions were discriminated by around 700 base pairs and these had resemblance with those of the Clausenae materials earlier deposited in Genbank at a 99–100% degree of identity. Additionally, the use of matK DNA sequences could positively confirm the identity as monophyletic. The highest total phenolic and total flavonoid content values (p < 0.05) were observed in the methanol extract of M. koenigii at 43.50 mg GAE/g extract and 66.13 mg QE/g extract, respectively. Furthermore, anethole was detected as the dominant compound in C. excavata (86.72%) and C. harmandiana (46.09%). Moreover, anethole (26.02%) and caryophyllene (21.15%) were identified as the major phytochemical compounds of M. koenigii. In terms of the biological properties, the M. koenigii methanol extract was found to display the greatest amount of antioxidant activity (DPPH; IC50 95.54 µg/mL, ABTS value 118.12 mg GAE/g extract, FRAP value 48.15 mg GAE/g extract), and also revealed the highest α-glucosidase and antihypertensive inhibitory activities with percent inhibition values of 84.55 and 84.95. Notably, no adverse effects on human peripheral blood mononuclear cells were observed with regard to all of the plant extracts. Furthermore, M. koenigii methanol extract exhibited promise against human lung cancer cells almost at 80% after 24 h and 90% over 48 h.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phytochemical Analysis and Evaluation of Antioxidant and Biological Activities of Extracts from Three Clauseneae Plants in Northern Thailand

Tanruean

Poolprasert

Suwannarach

et al. 2021

Plants

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“…The presence of bioactive Cand O-prenylated pyrano-and furocoumarins is quite common within Clausena species (Ouyang et al 2016;Ma et al 2018b;Wongthet et al 2018) and was also reported for C. lenis (Liu et al 2018). In contrast, furoquinoline derivatives (8-11) seem to be an extraordinary feature of this species, since there has been only one report of such compounds within the genus Clausena (He et al 2003b).…”

Section: Resultsmentioning

confidence: 67%

Chemical constituents of Clausena lenis

Wongthet

Schinnerl

Brecker

et al. 2020

Natural Product Research

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Phytochemical examination of Clausena lenis Drake (Rutaceae), collected in Thailand, led to the isolation of seven coumarins, four furoquinolines, two amides, and one flavonoid glycoside. Four of these compounds, one coumarine derivative named as gravelliferone A (3), two furoquinoline derivatives (kokusagenin A (8) and B (9)) and one amide, clausenalansamide H (13), are reported for the first time. Compound 3 was isolated from the root bark, compound 8 from the stem bark and compounds 9 and 13 from the leaves. The molecular structures of all isolated compounds were established by means of NMR experiments combined with mass spectrometry. Preliminary tests of the lipophilic stem bark extract against various human pathogenic bacteria strains revealed promising effects against Staphylococcus aureus ATCC 43300.

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“…Some species contain biologically active compounds such as saponins, steroids, cardiac glycosides, alkaloids, and flavonoids [1]. The genus Clausena is one of the genera of Rutaceae family, composed of about 15 species and 6 varieties [2,3]. These plants include trees or shrubs and were found in Africa, southern Asia, Australia and the Pacific Islands [4].…”

Section: Introductionmentioning

confidence: 99%

Chemical profiles and biological activities of acetone extracts of Curcuma xanthella

et al. 2022

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Summary Clausena is a genus of Rutaceae family commonly used in traditional medicine. This report aims to provide the brief review on the chemical components and bioactivities of essential oils (EOs) isolated from Clausena plants. The phyto-chemicals of EOs obtained from different plant parts of Clausena species are characterized by several chemical groups such as oxygenated sesquiterpene, oxygenated monoterpene, monoterpene hydrocarbons, sesquiterpene hydrocarbons, etc. In addition, the studied oils also possess the antimicrobial, insecticidal and larvicidal activities.

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Chemodiversity of Clausena excavata (Rutaceae) and related species: Coumarins and carbazoles

Cited by 6 publications

References 37 publications

Phytochemical Analysis and Evaluation of Antioxidant and Biological Activities of Extracts from Three Clauseneae Plants in Northern Thailand

Phytochemical Analysis and Evaluation of Antioxidant and Biological Activities of Extracts from Three Clauseneae Plants in Northern Thailand

Chemical constituents of Clausena lenis

Chemical profiles and biological activities of acetone extracts of Curcuma xanthella

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