2008
DOI: 10.3748/wjg.14.713
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Chemokine system polymorphisms, survival and hepatocellular carcinoma occurrence in patients with hepatitis C virus-related cirrhosis

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Cited by 40 publications
(33 citation statements)
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“…Several studies also discussed the relationship between polymorphisms of these genes and development and prognosis of cancers [15][16][17][18][19][20][21][22][23][24][25][26][27]. CCL2 rs1024611 was reported to be correlated with the metastases of breast cancer and nasopharyngeal carcinoma [15,16], and CXCL12 rs1801157 was found to be associated with the susceptibility or prognosis of several cancers including lung cancer [17][18][19][20][21][22][23][24][25][26][27].…”
Section: Introductionmentioning
confidence: 96%
“…Several studies also discussed the relationship between polymorphisms of these genes and development and prognosis of cancers [15][16][17][18][19][20][21][22][23][24][25][26][27]. CCL2 rs1024611 was reported to be correlated with the metastases of breast cancer and nasopharyngeal carcinoma [15,16], and CXCL12 rs1801157 was found to be associated with the susceptibility or prognosis of several cancers including lung cancer [17][18][19][20][21][22][23][24][25][26][27].…”
Section: Introductionmentioning
confidence: 96%
“…However, the lack of a loss of function mutation of the tumor suppressor gene p53 gene on CXCR4 expression in HCC indicated yet another unidentified mechanism [81] . However, an ambiguity as to whether CXCR4-CXCL12 actually promotes tumor growth as a downmodulation of CXCR4-CXCL12 expression in HCC, both in vitro and in vivo has been reported, where CXCL12/ CXCR4 also lacked an association with death and HCC recurrence [82] . Therefore, although it appears that the CXCL12-CXCR4 axis is indispensable in HCC, its precise role still remains paradoxical in this disease.…”
Section: Chemokine Ligand-chemokine Receptor Axismentioning
confidence: 99%
“…Genetic variations commonly occur in their regulatory regions, affecting chemokines gene transcription [82]. Although no clear associations with the development of HCC were initially reported [83,84], a recent prospective study suggested that chemokine RANTES G-403A dimorphism influenced the occurrence of HCC in patients with alcoholic cirrhosis [22].…”
Section: Inflammation Cytokine and Chemokine Systemsmentioning
confidence: 97%