Chemoradiation therapy using radiotherapy, systemic chemotherapy with 5-fluorouracil and nedaplatin, and intra-arterial infusion using carboplatin for locally advanced head and neck cancer – Phase II study

Fuwa, Nobukazu; Kodaira, T.; Furutani, Kazuhisa; Tachibana, Hideki; Nakamura, Tatsuya; Daimon, T.

doi:10.1016/j.oraloncology.2006.11.019

Cited by 16 publications

(8 citation statements)

References 24 publications

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“…Patients with advanced Stage T2 or greater carcinoma of the tongue and oral cavity underwent continuous intra-arterial chemotherapy in an effort to improve the treatment response. The details of the systemic and intra-arterial chemotherapy have been previously reported (9)(10)(11).…”

Section: Crt and Pndsmentioning

confidence: 99%

Clinical Usefulness of [(18)F] Fluoro-2-Deoxy-d-Glucose Uptake in 178 Head-and-Neck Cancer Patients With Nodal Metastasis Treated With Definitive Chemoradiotherapy: Consideration of Its Prognostic Value and Ability to Provide Guidance for Optimal Selection of Patients for Planned Neck Dissection

Inokuchi

Kodaira

Tachibana

et al. 2011

International Journal of Radiation Oncology*Biology*Physics

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Section: Crt and Pndsmentioning

confidence: 99%

Clinical Usefulness of [(18)F] Fluoro-2-Deoxy-d-Glucose Uptake in 178 Head-and-Neck Cancer Patients With Nodal Metastasis Treated With Definitive Chemoradiotherapy: Consideration of Its Prognostic Value and Ability to Provide Guidance for Optimal Selection of Patients for Planned Neck Dissection

Inokuchi

Kodaira

Tachibana

et al. 2011

International Journal of Radiation Oncology*Biology*Physics

Self Cite

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“…Eckardt et al (7), achieved marked clinical remission for patients with advanced head and neck squamous cell carcinoma by utilizing regional arterial infusion chemotherapy. A combination of 5-fluorourcil (5-Fu) and carboplatin has been demonstrated to be an effective treatment regimen for OSCC (8,9). Regional arterial infusion chemotherapy with 5-Fu and carboplatin for the treatment of OSCC has previously been utilized by our group, and achieved marked clinical efficacy (10,11).…”

Section: Introductionmentioning

confidence: 99%

Expression of mutant p53 in oral squamous cell carcinoma is correlated with the effectiveness of intra-arterial chemotherapy

Zhang

2015

Oncology Letters

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Abstract. The aim of the present study was to evaluate the correlation between the positive expression rate of mutant p53 and the clinical characteristics of patients with oral squamous cell carcinoma (OSCC), as well as the effectiveness of intra-arterial chemotherapy. Expression of mutant p53 in tumor tissues was determined by immunohistochemical analysis of 51 OSCC patients, prior to and following intra-arterial chemotherapy. Prior to intra-arterial chemotherapy, mutant p53 positive rates in patients with higher pathological grades were significantly higher than those of the patients with lower pathological grades. The mutant p53 positive rate in patients with lymph node metastasis was 73% (19/26), which was significantly higher than that of the patients without lymph node metastasis (20%, 5/25). Mutant p53 was expressed in 17% (3/18) of clinical phase II patients, while 64% (21/33) of clinical phase III and IV patients exhibited positive expression of mutant p53 (P<0.05). The mutant p53 positive rate in chemotherapy non-responsive patients was 69% (11/16), which was significantly higher than that in the chemotherapy-responsive patients (37%, 13/35). Mutant p53 positive rates were not significantly correlated with age, gender or the location of the tumor. The mutant p53 positive rate prior to chemotherapy was 47% (24/51), and decreased to 18% (9/51) following chemotherapy. Expression of mutant p53 was decreased in all 13 (100%) chemotherapy-responsive patients, while only 5 (45%) chemotherapy non-responsive patients exhibited reduced expression levels of mutant p53 (P<0.05). In conclusion, mutant p53 has a significant role in the differentiation, development and treatment guidance of OSCC. Intra-arterial chemotherapy with 5-fluorourcil and carboplatin potentially exerts a therapeutic effect by reducing the expression of mutant p53.

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“…In this method, a catheter is inserted via the STA in the preauricular area, and anticancer drugs are superselectively infused under fluoroscopic guidance into cancerous tissue which is fed by the maxillary, facial, and/or lingual arteries. Because the catheter is placed in the tumor-feeding arteries via the STA itself, this method can be safely used in combination with daily concurrent radiotherapy [3][4][5][6][7][8][9][10]. In particular, when this method was used to treat local advanced oral cancers at stage T3 or T4, many patients showed complete response (CR), without the presence of residual tumor cells in the pathological tissue [3,7,10].…”

Section: Introductionmentioning

confidence: 99%

Anatomical study of the external carotid artery and its branches for administration of superselective intra-arterial chemotherapy via the superficial temporal artery

et al. 2011

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show abstract

Chemoradiation therapy using radiotherapy, systemic chemotherapy with 5-fluorouracil and nedaplatin, and intra-arterial infusion using carboplatin for locally advanced head and neck cancer – Phase II study

Cited by 16 publications

References 24 publications

Clinical Usefulness of [(18)F] Fluoro-2-Deoxy-d-Glucose Uptake in 178 Head-and-Neck Cancer Patients With Nodal Metastasis Treated With Definitive Chemoradiotherapy: Consideration of Its Prognostic Value and Ability to Provide Guidance for Optimal Selection of Patients for Planned Neck Dissection

Clinical Usefulness of [(18)F] Fluoro-2-Deoxy-d-Glucose Uptake in 178 Head-and-Neck Cancer Patients With Nodal Metastasis Treated With Definitive Chemoradiotherapy: Consideration of Its Prognostic Value and Ability to Provide Guidance for Optimal Selection of Patients for Planned Neck Dissection

Expression of mutant p53 in oral squamous cell carcinoma is correlated with the effectiveness of intra-arterial chemotherapy

Anatomical study of the external carotid artery and its branches for administration of superselective intra-arterial chemotherapy via the superficial temporal artery

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