Chemoselective Peptide Ligation: A Privileged Tool for Protein Synthesis

Three-ring circus! Surprisingly complex molecular acrobatics are observed in the mechanism of the α-ketoacid-hydroxylamine amide-forming ligation reaction. Although this remarkable reaction can already be used for the chemoselective union of large, unprotected peptide fragments the elucidated mechanism provides important clues to extending its application to larger and more complex biological targets.

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ChemInform Abstract: Chemoselective Peptide Ligation: A Privileged Tool for Protein Synthesis

Hackenberger

Bode

Schwarzer

2012

ChemInform

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Chemoselective Peptide Ligation: A Privileged Tool for Protein Synthesis

Cited by 5 publications

References 252 publications

The Mechanism of the α‐Ketoacid–Hydroxylamine Amide‐Forming Ligation

The Mechanism of the α‐Ketoacid–Hydroxylamine Amide‐Forming Ligation

The Mechanism of the α‐Ketoacid–Hydroxylamine Amide‐Forming Ligation

ChemInform Abstract: Chemoselective Peptide Ligation: A Privileged Tool for Protein Synthesis

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