Chemosensitization of Tumor Cells by Phenolic Antioxidants: The Role of the Nrf2 Transcription Factor

Мартинович, Г. Г.; Мартинович, И. В.; Vcherashniaya, A. V.; Зенков, Н. К.; Menshchikova, E. B.; Черенкевич, С. Н.

doi:10.1134/s000635092006010x

Cited by 6 publications

(1 citation statement)

References 158 publications

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“…ROS levels correlate with tumor aggressiveness and negative prognosis (Milaeva et al 2019). Such a multidirectional manner is associated with a plethora of factors, including the structure of antioxidant compounds, specific properties of metabolic products, origin of the tumor model and gender of tumor bearing animals (Mendelsohn et al 2014;Martinovich et al 2020). A significant anti-metastatic effect, which is non-linearly dependent on the dose presumes the roles for the balance of oxidation/reduction, mitochondrial permeability and swelling (Le Gal et al 2015;Durnova et al 2019;Puzakov et al 2019), and immune surveillance.…”

Section: Resultsmentioning

confidence: 99%

Impact of organotin compounds on the growth of epidermoid Lewis carcinoma

Додохова¹,

Сафроненко²,

Котиева³

et al. 2021

RRP

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Introduction: Search for new compounds with a broad antitumor and antimetastatic potency due to multiple targeting remains important in medicinal chemistry, pharmacology and oncology. We report the efficacy of hybrid organotin agents bis-(3,5-di-tert-butyl-4-hydroxyphenylthiolate) dimethyltin (Ме3) and (3,5-di-tert-butyl-4-hydroxyphenylthiolate) triphenyltin (Ме5). Materials and methods: The compounds were administered to mice bearing the spontaneously metastatic epidermoid Lewis lung carcinoma (LLC). The efficacy of the treatment was evaluated by mean life span, percentage of tumor growth inhibition, number of lung metastases, frequency of metastasis, tumor weight 21 days after tumor cell inoculation, and a degree of lung damage according to the method of D. Tarin and J.E. Price. Results and discussion: For new organotin compounds containing an antioxidant protective fragment of 2,6-di-tert-butylphenol, moderate antitumor and pronounced antimetastatic effects were revealed in the Lewis model of epidermoid lung carcinoma; more active for Me5. Some features of the development of the process of metastasis were recorded with the introduction of various doses of hybrid organotin compounds. Conclusion: Substances Ме3 and Ме5 possess specific activity on the model under investigation, which allows one to suggest these organotins as promising series of antitumor and antimetastatic agents with multiple targeting mode of action.

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Section: Resultsmentioning

confidence: 99%

Impact of organotin compounds on the growth of epidermoid Lewis carcinoma

Додохова¹,

Сафроненко²,

Котиева³

et al. 2021

RRP

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The Protective Effect of Hydrogen Peroxide on Erythrocyte Hemolysis Induced by Silver Nanoparticles

Voinarovski

Мартинович

2022

BIOPHYSICS

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The mechanisms of regulation of adaptation of erythrocytes by hydrogen peroxide during hemolysis induced by silver nanoparticles have been studied using numerical modeling and spectrophotometric analysis. It was shown that silver nanoparticles induced erythrocyte hemolysis, the rate of which depended on the total concentration of silver and the ion content in the solution. Hemolysis of erythrocytes with silver nitrate proceeded twice as fast as with nanoparticles. It was found that hydrogen peroxide increased the structural stability of erythrocytes during hemolysis induced by silver nanoparticles and silver nitrate. The range of hydrogen peroxide concentrations at which an increase in the proportion of non-hemolysed cells (the hormesis region) was observed depended on the time of cell destruction under the action of a damaging factor. The maximum of hormesis was observed at a concentration of hydrogen peroxide of 1250 μM under damage induced by silver nanoparticles; it was 700 μM under damage induced by silver nitrate. Numerical modeling has shown that the dependence of the maximum of hormesis on the concentration of extracellular hydrogen peroxide and incubation time was due to the dynamic nature of cytoplasmic mechanisms regulating the ratio of membrane complexes of methemoglobin and ferryl hemoglobin.

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Free Radicals and Signal Transduction in Cells

Martinovich,

Voinarouski

et al. 2023

BIOPHYSICS

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Chemosensitization of Tumor Cells by Phenolic Antioxidants: The Role of the Nrf2 Transcription Factor

Cited by 6 publications

References 158 publications

Impact of organotin compounds on the growth of epidermoid Lewis carcinoma

Impact of organotin compounds on the growth of epidermoid Lewis carcinoma

The Protective Effect of Hydrogen Peroxide on Erythrocyte Hemolysis Induced by Silver Nanoparticles

Free Radicals and Signal Transduction in Cells

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