“…On the other hand, wound healing disturbances and a failure to repair the wound may occur secondary to the reduced migratory abilities, and could promote fistula formation. Fibroblasts derived from diseased tissue associated with fibrosis exhibit alterations in their migratory potential, as is the case in interstitial fibrosis associated with collagen vascular disease, sarcoidosis, 24 mucopolysaccaridosis, 25 and amyloidosis, 26 but both increased and decreased migration was noted. IBD CLPF exhibit an intrinsically reduced migratory potential compared to controls.…”