Chemotherapy: some potential risks under antineoplastic drugs handling

Соленова, Л. Г.; Якубовская, М. Г.

doi:10.17650/2313-805x-2017-4-3-10-20

Cited by 3 publications

(1 citation statement)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…В полной мере это относится к медицинским учреждениям онкологического профиля, в лечебном арсенале которых радиологические методы и химиотерапевтические средства, обладающие доказанными канцерогенными для человека свойствами, действие которых сочетается с высокими психоэмоциональными нагрузками. Воздействие факторов различной природы, действующих в комплексе, может повышать онкологический риск у медицинских работников, о чем свидетельствуют данные, полученные в широкомасштабных зарубежных эпидемиологических исследованиях медицинских работников [3,4]. Актуальность отечественных эпидемиологических исследований медицинских работников не подлежит сомнению.…”

unclassified

Epidemiological monitoring of cancer risk in cancer center workers

Соленова

2019

Usp. mol. onkol

Self Cite

View full text Add to dashboard Cite

Based on the results of cancer monitoring in the staff of a large Cancer Center cancer risk research was performed using the method of nested “case–control” study within a cohort. The cohort comprised 7269 persons who were followed up through the cancer-register of the Cancer Center. Four hundred eighty-four (139 male and 345 female) cancer cases were revealed. For every case a control individual of the same sex and age was randomly selected from the staff who had no cancer as of January 1, 2019. A statistically insignificant increase in the overall cancer risk was observed in male operational staff (odds ratio (OR) being 1.14, 95 % confidence interval (CI) 0.64–2.05) and other doctorsclinicians (OR 1.36; 95 % CI 0.68–2.73). In a combined group of male clinicians and experimenters 4 cases of thyroid cancer were revealed and no members of this group were present in controls. An insignificantly increased risk of hemoblastoses, skin and brain cancer were also observed in this group. In the female stuff an insignificantly increased risk of all cancer sites combined was recorded in operational group (OR 1.28; 95 % CI 0.58–2.87) and nurses (OR 1.21; 95 % CI 0.85–1.72), as well as in the female stuff of experimental scientific units (OR 1.31; 95 % CI 0.90–1.92). An insignificant increase in breast cancer risk was observed in women clinicians and experimenters, exposed to the occupational factors. Female employees of experimental scientific units demonstrated a statistically significant increased risk of digestive organs cancer (OR 2.95; 95 % CI 1.14–7.67) and hemoblastoses (OR 5.71; 95 % CI 1.05–31.07). The results of the study demonstrate the need for epidemiological monitoring and data accumulation on cancer risk in different groups of medical workers.

show abstract

unclassified

Epidemiological monitoring of cancer risk in cancer center workers

Соленова

2019

Usp. mol. onkol

Self Cite

View full text Add to dashboard Cite

show abstract

Healthcare workers: occupational carcinogenic factors and cancer risk

Соленова

Nekrasova

2018

Usp. mol. onkol

Self Cite

View full text Add to dashboard Cite

The number of healthcare workers is over two million in Russia. Many of them are exposed to hazardous physical, chemical and biological occupational factors acting along with psychological strain. The results of large epidemiological studies carried out in various countries revealed greater cancer risk in physicians and nurses: cancer of the breast, skin, brain and other sites. Higher cancer risk of lung, breast, uterine, ovary, brain is considered to be associated with ionizing radiation. The female healthcare workers who handle antineoplastic drugs showed a greater risk of birth defects in offspring, spontaneous abortions and breast cancer. In Russia, the growing number of accidents among healthcare workers following transmission of infection by carcinogenic biological factors such as HBV and HIV is observed. Higher risk of reproductive impairments, hyperplasia of the breast and uterine tissues, breast cancer are revealed in nurses working the night shift. In Russia, there is lack of epidemiological studies of cancer risk among healthcare workers, the number of medical personal exposed to occupational carcinogens is unknown. That all does not show the actual situation in our country and does not allow setting priorities in cancer prevention among medical workers.

show abstract

About the Possibility of Toxic Effects Developing in Contact With N-Nitrosoalkylurea Derivative - Lysomustine

Stosman

Lukovnikova

Sidorin

et al. 2020

Toksikologičeskij vestnik

View full text Add to dashboard Cite

The paper presents the results of a study on the possibility of toxic effects developing in contact with the antitumor drug – lysomustine - to assess the health risk in the manufacture of the finished dosage form and its use. The work was performed on 40 outbred rats, 40 guinea pigs and 114 outbred mice. The experimental study has showed that lysomustine does not irritate intact skin, is not a potential allergen, has no skin-resorptive effect, does not cause reproductive disorders. The drug reveales mutagenic properties inherent in many cytostatics, representatives of the class of N-nitrosoalkylureas. The research results allow to conclude that the presence of the drug in the air of industrial premises and on the skin of workers in its manufacture and use of the finished dosage form is unacceptable.

show abstract

Chemotherapy: some potential risks under antineoplastic drugs handling

Cited by 3 publications

References 46 publications

Epidemiological monitoring of cancer risk in cancer center workers

Epidemiological monitoring of cancer risk in cancer center workers

Healthcare workers: occupational carcinogenic factors and cancer risk

About the Possibility of Toxic Effects Developing in Contact With N-Nitrosoalkylurea Derivative - Lysomustine

Contact Info

Product

Resources

About