Chest Roentgenogram Classification and Clinical Parameters in Patients with Active Pulmonary Tuberculosis.

Murate, Takanao; Shimokata, Kaoru; Watanabe, Atsushi; Ichiyama, Satoshi; Saitô, Hiroshi; Yamori, Sadaaki; Nomura, Fumio; Iwahara, T; Sakai, Shuzo; Nakanishi, Kazuo; Nishiwaki, K; Ohgimi, Tatsuo

doi:10.2169/internalmedicine.31.185

Cited by 3 publications

(4 citation statements)

References 7 publications

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“…(4) Several routine laboratory tests including serum concentration of “C reactive protein (CRP) at entry,” (total) “Albumin at entry,” and “CRP after 60 days of treatment” were simultaneously performed. (5) Severity of chest radiography at entry: “The Japanese Society for Tuberculosis Classification” (1959) was applied [ 20 ]. Briefly, tuberculosis lesions are classified by chest X-ray findings as type (cavity) and extent.…”

Section: Methodsmentioning

confidence: 99%

“…“X-ray type (cavity)” was subdivided from III to I (III: no cavity, II: morbid foci other than I, and I: widespread cavities) and “X-ray extent” from 1 to 3 (1: minimal, 2: moderate, and 3: severe). These markers and classifications were chosen because serum albumin levels reaction to the tuberculin skin test, the Gaffky scale, and negative conversion time are significantly correlated with both type and extent [ 20 ]. If patients contracted hilar glandular tuberculosis and/or tuberculosis lymphadenopathy, the evaluation of (1), (2), and (3) was excluded and that of (4) and (5) was included for the analysis because bacterial presentation in the sputum is rare.…”

Section: Methodsmentioning

confidence: 99%

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Evaluation of Humoral Immunity toMycobacterium tuberculosis-Specific Antigens for Correlation with Clinical Status and Effective Vaccine Development

Niki

Suzukawa

Akashi

et al. 2015

Journal of Immunology Research

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Although tuberculosis remains a major global health problem, Bacille Calmette-Guérin (BCG) is the only available vaccine. However, BCG has limited applications, and a more effective vaccine is needed. Cellular mediated immunity (CMI) is thought to be the most important immune response for protection against Mycobacterium tuberculosis (Mtb). However, the recent failure of a clinical trial for a booster BCG vaccine and increasing evidence of antibody-mediated immunity prompted us to evaluate humoral immunity to Mtb-specific antigens. Using Enzyme-Linked ImmunoSpot and Enzyme-Linked ImmunoSorbent Assays, we observed less correlation of both CMI and IgG titers with patient clinical status, including serum concentration of C reactive protein. However, IgA titers against Mtb were significantly correlated with clinical status, suggesting that specific IgA antibodies protect against Mtb proliferation. In addition, in some cases, IgA antibody titers were significantly associated with the serum concentration of total albumin, which supports the idea that humoral immunity can be influenced by the nutritional status. Based on these observations, we propose that the induction of humoral immunity should be included as an option in TB vaccine development strategies.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Evaluation of Humoral Immunity toMycobacterium tuberculosis-Specific Antigens for Correlation with Clinical Status and Effective Vaccine Development

Niki

Suzukawa

Akashi

et al. 2015

Journal of Immunology Research

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“…It has been reported that malnutrition and hypoalbuminemia were related to fatality of TB in the Far East and Japan, respectively [11,12]. Malnutrition contributes to the morbidity of TB and may also contribute to mortality.…”

Section: Discussionmentioning

confidence: 99%

Deaths in Patients with Pulmonary Tuberculosis: An Analysis of a Chest Diseases Hospital in Istanbul, Turkey

Kartaloğlu¹,

İlvan²,

Kılıç³

et al. 2003

Med Princ Pract

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Objective: To evaluate the medical records of patients with pulmonary tuberculosis in order to determine the inhospital mortality rate. Materials and Methods: Medical records of 22,651 patients with pulmonary tuberculosis admitted to Gulhane Military Medical Academia, Camlica Chest Diseases Hospital, Istanbul, Turkey from 1977 to 1999 were examined. Results: Of the 22,651 patients, 133 (0.58%) died: 117 male and 16 female, mean age 41.5 ± 20.7 years. The mean length of hospital stay was 15.8 ± 25.9 days and it increased yearly (p = 0.004). There was no significant difference in hospital mortality rate of tuberculosis within years. Forty-nine patients had chronic and/or far advanced tuberculosis, 36 of them had concomitant diseases. Thirteen patients had miliary and/or tuberculous meningitis, 3 multi drug-resistant tuberculosis, another 3 had pneumothorax, and 2 empyema. These patients had significantly lower prognostic nutritional index than those patients who recovered from pulmonary tuberculosis (p = 0.025). Conclusion: Inhospital mortality rate of tuberculosis did not change in the last 23 years. We suggest that pulmonary tuberculosis will continue to be a significant cause of death and therefore important health care problem for Turkey in the 21st century.

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“…Information on previous medical history and clinical signs and symptoms were also collected as previously described. "The Japanese Society for Tuberculosis Classification" (1959) was applied to measure the severity of chest radiography at entry [36]. Briefly, tuberculosis lesions were classified by chest X-ray findings as type (cavity) and extent.…”

Section: Participantsmentioning

confidence: 99%

Nutritional status positively impacts humoral immunity against its Mycobacterium tuberculosis, disease progression, and vaccine development

et al. 2020

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Nutritional status contributes to the regulation of immune responses against pathogens, and malnutrition has been considered as a risk factor for tuberculosis (TB). Mycobacterium tuberculosis (Mtb), the causative agent of TB, can modulate host lipid metabolism and induce lipid accumulation in macrophages, where the bacilli adopt a dormant phenotype. In addition, serum lipid components play dual roles in the regulation of and protection from Mtb infection. We analyzed the relationship between nutritional status and the humoral immune response in TB patients. We found that serum HDL levels are positively correlated with the serum IgA specific for Mtb antigens. Analysis of the relationship between serum nutritional parameters and clinical parameters in TB patients showed that serum albumin and CRP levels were negatively correlated before treatment. We also observed reduced serum LDL levels in TB patients following treatment. These findings may provide insight into the role of serum lipids in host immune responses against Mtb infection. Furthermore, improving the nutritional status may enhance vaccination efficacy.

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Chest Roentgenogram Classification and Clinical Parameters in Patients with Active Pulmonary Tuberculosis.

Cited by 3 publications

References 7 publications

Evaluation of Humoral Immunity toMycobacterium tuberculosis-Specific Antigens for Correlation with Clinical Status and Effective Vaccine Development

Evaluation of Humoral Immunity toMycobacterium tuberculosis-Specific Antigens for Correlation with Clinical Status and Effective Vaccine Development

Deaths in Patients with Pulmonary Tuberculosis: An Analysis of a Chest Diseases Hospital in Istanbul, Turkey

Nutritional status positively impacts humoral immunity against its Mycobacterium tuberculosis, disease progression, and vaccine development

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