Chest Tuberculosis in Children

Naranje, Priyanka; Bhalla, Ashu Seith; Sherwani, Poonam

doi:10.1007/s12098-018-02847-7

Cited by 15 publications

(15 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Radiologic imaging with chest radiography is a standard investigation when pulmonary TB is suspected [33, 34]. Hilar lymphadenopathy and consolidation were most frequently observed in all age-groups [35]. Despite the small number of included children, bronchial compression was most observed in children aged <2 years, which is a typical finding in this age-group known from the prechemotherapy era [6].…”

Section: Discussionmentioning

confidence: 99%

Pediatric Tuberculosis Disease during Years of High Refugee Arrivals: A 6-Year National Prospective Surveillance Study

et al. 2021

View full text Add to dashboard Cite

Background: In Europe, surveillance and monitoring of pediatric tuberculosis (TB) remains important, particularly in the light of migration in recent years. The aim of the study was to evaluate incidence rates of childhood TB and detailed diagnostic pathways and treatment. Methods: Data were collected through the Swiss Pediatric Surveillance Unit (SPSU) from December 2013 to November 2019. Monthly notifications are obtained from the 33 pediatric hospitals in the SPSU, and a detailed questionnaire was sent out upon notification. Inclusion criteria were children and adolescents aged up to 15 years with culture- or molecular-confirmed TB disease or for whom a treatment with ≥3 antimycobacterial drugs had been initiated. Data were compared with age-matched notification data from the Swiss Federal Office of Public Health (FOPH). Results: Of the 172 cases notified to SPSU, a detailed questionnaire was returned for 161 (93%) children, of which 139 met the inclusion criteria. Reasons for exclusion were age >15 years, double reporting, and not fulfilling the criteria for TB disease. During the same time period, 172 pediatric TB cases were reported to the FOPH, resulting in an incidence of 2.1 per 100,000, ranging from 1.4 to 2.8 per year, without a clear trend over time. In the 64 (46.0%) foreign-born children, incidence rates were higher and peaked in 2016, with 13.7 per 100,000 (p = 0.018). The median interval between arrival in Switzerland and TB diagnosis was 5 (IQR 1–21) months, and 80% were diagnosed within 24 months of arrival. In 58% of the cases, TB disease was confirmed by culture or molecular assays. Age >10 years, presence of fever, or weight loss were independent factors associated with confirmed TB. Conclusion: The annual pediatric TB incidence rate only varied among foreign-born children and was highest in 2016 when refugee influx peaked in Europe. Importantly, most foreign-born children with TB were diagnosed within 2 years after arrival in Switzerland. Thus, the early period after arrival in Switzerland is associated with a higher risk of TB disease in children, and this should be considered for screening guidance in refugees.

show abstract

Section: Discussionmentioning

confidence: 99%

Pediatric Tuberculosis Disease during Years of High Refugee Arrivals: A 6-Year National Prospective Surveillance Study

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Se ha reportado que la mayoría de los contactos son familiares del paciente, habitantes o no de la misma vivienda 5,8 , lo que se confirmó en este estudio. Los contactos intradomiciliarios que han sido descritos como más significativos son los cuidadores principales 21,40 , igual a los reportados por nuestro estudio (madre, padre y abuelos).…”

Section: Discussionunclassified

“…La ausencia de hallazgos en la placa de tórax no descarta la presencia de TB en pediatría 5,21,40 ; el 10 % de los pacientes con TB en SNC y el 40 % de los pacientes con TB ganglionar en cuello pueden tener ausencia de hallazgos en esta ayuda diagnóstica 10,19,21 . Lo anterior se evidenció en nuestro estudio donde 11 pacientes con compromiso extratorácico (SNC y ganglionar en cuello) tenían placa de tórax normal.…”

Section: Discussionunclassified

Caracterización de los pacientes menores de 15 años con tuberculosis en el Hospital Universitario San Vicente Fundación, 2011-2018

Jaramillo-Zapata

Morales-Múnera

Niño-Serna

2020

Infect

View full text Add to dashboard Cite

La Tuberculosis (TB) es la enfermedad infecciosa que más daño ha causado a la especie humana a lo largo de toda la historia, tanto por el número de enfermos como de muertos. Se ha calculado que en los últimos 200 años ha sido la responsable de la muerte de más de 1.000 millones de personas (1). La TB sigue siendo una de las enfermedades infecciosas más importante en esta época, y es el fiel reflejo de las enormes diferencias económicas y sociales que siguen existiendo en la población mundial1,2. Objetivo: describir las características demográficas y clínicas de los pacientes menores de 15 años con TB en el período 2011 – 2018 en un Hospital de cuarto nivel de la ciudad de Medellín – Colombia. Metodología: estudio observacional descriptivo de corte transversal. Incluyó pacientes menores de 15 años que asistieron al Hospital Universitario San Vicente Fundación (HUSVF) a quienes se les diagnosticó TB pulmonar y/o extrapulmonar, en el período comprendido entre enero de 2011 a diciembre de 2018. Resultados: 184 historias de pacientes con TB cumplieron los criterios de inclusión. Setenta y un pacientes (38.6 %) correspondían a TB pulmonar, 59 (32 %) a otras TB intratorácicas y 54 (29.3 %) a TB extrapulmonar. Las formas de TB más frecuentes fueron: ganglionar, del sistema nervioso central (SNC) y diseminada. De los niños menores de 5 años, el 50 % presentaron algún grado de desnutrición. La confirmación microbiológica por cultivo o baciloscopia (BK) estuvo presente en 91 pacientes (49.4 %) y por Reacción en Cadena de la Polimerasa (PCR) en 72 (39.1 %). Conclusiones: la TB infantil requiere un alto índice de sospecha. La suma de criterios es muy importante para su diagnóstico dada la fisiopatología de la enfermedad, sin embargo la búsqueda exhaustiva de la micobacteria es una estrategia útil para un tratamiento efectivo.

show abstract

“…Imaging is an integral part in the diagnosis of pulmonary tuberculosis in children. The article by Naranje et al discusses the role of various imaging modalities like chest radiography, ultrasonography, computed tomography, magnetic resonance imaging, and functional scans like FDG PET CT [3]. Authors have detailed about the optimal use X-ray film of chest and its interpretations.…”

mentioning

confidence: 99%

“…Chest Ultrasonography (USG) is an emerging investigation and its role in the diagnosis and monitoring is evolving. Naranje et al discuss current status of USG specifically in the context of pulmonary tuberculosis [3].…”

mentioning

confidence: 99%